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Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells

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Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, 300041 Timişoara, Romania
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Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary
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Pharmazentrum frankfurt/ZAFES, Clinic of the Goethe University, D-60590 Frankfurt/Main, Germany
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Faculty of Pharmacy, “Gr.T.Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
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Banat University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania”, 300645 Timisoara, Romania
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Faculty of Medicine, “Victor Babeş” University of Medicine and Pharmacy, 300041 Timişoara, Romania
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(11), 3624; https://doi.org/10.3390/ijms19113624
Received: 11 October 2018 / Revised: 26 October 2018 / Accepted: 9 November 2018 / Published: 16 November 2018
(This article belongs to the Section Bioactives and Nutraceuticals)
Chamomile, parsley, and celery represent major botanical sources of apigenin, a well-known flavone with chemopreventive properties. The aim of this study was to assess the phytochemical composition, antioxidant, and anti-inflammatory potential of methanol extracts obtained from chamomile, parsley, and celery collected from Romania, as well as the biological activity against A375 human melanoma and human dendritic cells. Results have shown that all three extracts are rich in polyphenolic compounds and flavonoids, and they generate a radical scavenger capacity, iron chelation potential, as well as lipoxygenase inhibition capacity. Chamomile and celery extracts present weak antiproliferative and pro-apoptotic properties in the set experimental conditions, while parsley extract draws out significant pro-apoptotic potential against A375 human melanoma cells. Parsley and chamomile extracts affected the fibroblast-like morphology of the screened tumor cell line. On the other hand, chamomile and celery extracts abrogated the expansion of LPS-activated dendritic cells, while the metabolic activity was attenuated by stimulation with celery extract; chamomile and parsley extracts had no effect upon this parameter. Chamomile and parsley extracts incubation with naive dendritic cells did not trigger cytokine secretion (TNF-alpha, IL-6, IL-10), but celery extract stimulation significantly reduced the anti-inflammatory, cytokine IL-10. View Full-Text
Keywords: chamomile; parsley; celery; antioxidant; anti-inflammatory; A375 human melanoma cells; dendritic cells chamomile; parsley; celery; antioxidant; anti-inflammatory; A375 human melanoma cells; dendritic cells
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MDPI and ACS Style

Danciu, C.; Zupko, I.; Bor, A.; Schwiebs, A.; Radeke, H.; Hancianu, M.; Cioanca, O.; Alexa, E.; Oprean, C.; Bojin, F.; Soica, C.; Paunescu, V.; Dehelean, C.A. Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells. Int. J. Mol. Sci. 2018, 19, 3624. https://doi.org/10.3390/ijms19113624

AMA Style

Danciu C, Zupko I, Bor A, Schwiebs A, Radeke H, Hancianu M, Cioanca O, Alexa E, Oprean C, Bojin F, Soica C, Paunescu V, Dehelean CA. Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells. International Journal of Molecular Sciences. 2018; 19(11):3624. https://doi.org/10.3390/ijms19113624

Chicago/Turabian Style

Danciu, Corina, Istvan Zupko, Andrea Bor, Anja Schwiebs, Heinfried Radeke, Monica Hancianu, Oana Cioanca, Ersilia Alexa, Camelia Oprean, Florina Bojin, Codruta Soica, Virgil Paunescu, and Cristina A. Dehelean 2018. "Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells" International Journal of Molecular Sciences 19, no. 11: 3624. https://doi.org/10.3390/ijms19113624

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