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The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis

1
Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
2
Division for Health Service Promotion, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
3
Hastings Center for Pulmonary Research, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
4
Department of Immunology, Genetics and Pathology, Uppsala University, SE-75185 Uppsala, Sweden
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(11), 3611; https://doi.org/10.3390/ijms19113611
Received: 26 September 2018 / Revised: 12 November 2018 / Accepted: 14 November 2018 / Published: 15 November 2018
(This article belongs to the Special Issue Inflammation and Cancer 2018)
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth factor (TGF)-β signaling plays a central role in tissue fibrosis and tumorigenesis. TGF-β-mediated pathological changes that occur in IPF lung tissue may promote the process of field cancerization and provide the microenvironment favorable to cancer initiation and progression. This review summarizes the current knowledge related to IPF pathogenesis and explores the molecular mechanisms that underlie the occurrence of lung cancer in the background of IPF, with an emphasis on the multifaceted effects of TGF-β signaling. View Full-Text
Keywords: idiopathic pulmonary fibrosis; non-small cell lung cancer; transforming growth factor-β; extracellular matrix; tumor microenvironment; usual interstitial pneumonia idiopathic pulmonary fibrosis; non-small cell lung cancer; transforming growth factor-β; extracellular matrix; tumor microenvironment; usual interstitial pneumonia
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MDPI and ACS Style

Saito, A.; Horie, M.; Micke, P.; Nagase, T. The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis. Int. J. Mol. Sci. 2018, 19, 3611.

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