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Open AccessReview

Impact of Melatonin in Solid Organ Transplantation—Is It Time for Clinical Trials? A Comprehensive Review

1
Department General, Visceral and Transplant Surgery, Medical University of Graz, Graz 8036, Austria
2
Transplant Center Graz, Medical University of Graz, Graz 8036, Austria
3
Faculty of Medicine, Vilnius University, Vilnius 03101, Lithuania
4
Department of Abdominal Surgery and Oncology, National Cancer Institute, Vilnius 08660, Lithuania
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(11), 3509; https://doi.org/10.3390/ijms19113509
Received: 14 October 2018 / Revised: 5 November 2018 / Accepted: 6 November 2018 / Published: 8 November 2018
Solid organ transplantation is the “gold standard” for patients with end-stage organ disease. However, the supply of donor organs is critical, with an increased organ shortage over the last few years resulting in a significant mortality of patients on waiting lists. New strategies to overcome the shortage of organs are urgently needed. Some experimental studies focus on melatonin to improve the donor pool and to protect the graft; however, current research has not reached the clinical level. Therefore, this review provides a comprehensive overview of the data available, indicating that clinical evaluation is warranted. View Full-Text
Keywords: heart transplantation; lung transplantation; liver transplantation; kidney transplantation; pancreas transplantation; melatonin; review heart transplantation; lung transplantation; liver transplantation; kidney transplantation; pancreas transplantation; melatonin; review
MDPI and ACS Style

Stiegler, P.; Bausys, A.; Leber, B.; Strupas, K.; Schemmer, P. Impact of Melatonin in Solid Organ Transplantation—Is It Time for Clinical Trials? A Comprehensive Review. Int. J. Mol. Sci. 2018, 19, 3509.

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