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Int. J. Mol. Sci. 2018, 19(11), 3509; https://doi.org/10.3390/ijms19113509

Impact of Melatonin in Solid Organ Transplantation—Is It Time for Clinical Trials? A Comprehensive Review

1
Department General, Visceral and Transplant Surgery, Medical University of Graz, Graz 8036, Austria
2
Transplant Center Graz, Medical University of Graz, Graz 8036, Austria
3
Faculty of Medicine, Vilnius University, Vilnius 03101, Lithuania
4
Department of Abdominal Surgery and Oncology, National Cancer Institute, Vilnius 08660, Lithuania
*
Author to whom correspondence should be addressed.
Received: 14 October 2018 / Revised: 5 November 2018 / Accepted: 6 November 2018 / Published: 8 November 2018
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Abstract

Solid organ transplantation is the “gold standard” for patients with end-stage organ disease. However, the supply of donor organs is critical, with an increased organ shortage over the last few years resulting in a significant mortality of patients on waiting lists. New strategies to overcome the shortage of organs are urgently needed. Some experimental studies focus on melatonin to improve the donor pool and to protect the graft; however, current research has not reached the clinical level. Therefore, this review provides a comprehensive overview of the data available, indicating that clinical evaluation is warranted. View Full-Text
Keywords: heart transplantation; lung transplantation; liver transplantation; kidney transplantation; pancreas transplantation; melatonin; review heart transplantation; lung transplantation; liver transplantation; kidney transplantation; pancreas transplantation; melatonin; review
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Stiegler, P.; Bausys, A.; Leber, B.; Strupas, K.; Schemmer, P. Impact of Melatonin in Solid Organ Transplantation—Is It Time for Clinical Trials? A Comprehensive Review. Int. J. Mol. Sci. 2018, 19, 3509.

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