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Drosophila Models of Sporadic Parkinson’s Disease

Department of Genetics and Evolution, Sciences III, University of Geneva, 30 Quai Ernest-Ansermet, CH-1211 Geneva-4, Switzerland
Int. J. Mol. Sci. 2018, 19(11), 3343;
Received: 6 September 2018 / Revised: 22 October 2018 / Accepted: 23 October 2018 / Published: 26 October 2018
(This article belongs to the Special Issue Drosophila Model and Human Disease)
Parkinson’s disease (PD) is the most common cause of movement disorders and is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. It is increasingly recognized as a complex group of disorders presenting widely heterogeneous symptoms and pathology. With the exception of the rare monogenic forms, the majority of PD cases result from an interaction between multiple genetic and environmental risk factors. The search for these risk factors and the development of preclinical animal models are in progress, aiming to provide mechanistic insights into the pathogenesis of PD. This review summarizes the studies that capitalize on modeling sporadic (i.e., nonfamilial) PD using Drosophila melanogaster and discusses their methodologies, new findings, and future perspectives. View Full-Text
Keywords: sporadic Parkinson’s disease; Drosophila; animal model sporadic Parkinson’s disease; Drosophila; animal model
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Nagoshi, E. Drosophila Models of Sporadic Parkinson’s Disease. Int. J. Mol. Sci. 2018, 19, 3343.

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