Emerging Roles of TWIK-1 Heterodimerization in the Brain
AbstractTwo-pore domain K+ (K2P) channels play essential roles in regulating resting membrane potential and cellular excitability. Although TWIK-1 (TWIK—tandem of pore domains in a weak inward rectifying K+ channel) was the first identified member of the K2P channel family, it is only in recent years that the physiological roles of TWIK-1 have been studied in depth. A series of reports suggest that TWIK-1 may underlie diverse functions, such as intrinsic excitability of neurons, astrocytic passive conductance, and astrocytic glutamate release, as a homodimer or heterodimer with other K2P isotypes. Here, we summarize expression patterns and newly identified functions of TWIK-1 in the brain. View Full-Text
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Cho, C.-H.; Hwang, E.M.; Park, J.-Y. Emerging Roles of TWIK-1 Heterodimerization in the Brain. Int. J. Mol. Sci. 2018, 19, 51.
Cho C-H, Hwang EM, Park J-Y. Emerging Roles of TWIK-1 Heterodimerization in the Brain. International Journal of Molecular Sciences. 2018; 19(1):51.Chicago/Turabian Style
Cho, Chang-Hoon; Hwang, Eun M.; Park, Jae-Yong. 2018. "Emerging Roles of TWIK-1 Heterodimerization in the Brain." Int. J. Mol. Sci. 19, no. 1: 51.
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