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Int. J. Mol. Sci. 2018, 19(1), 287;

Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer

Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng-Kung University, Tainan 70101, Taiwan
The Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, Tainan 70101, Taiwan
Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan 707010, Taiwan
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40401, Taiwan
Department of Biomedical Informatics, Asia University, Taichung 41354, Taiwan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 12 December 2017 / Revised: 9 January 2018 / Accepted: 16 January 2018 / Published: 18 January 2018
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
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Cancer is a major cause of death. The outcomes of current therapeutic strategies against cancer often ironically lead to even increased mortality due to the subsequent drug resistance and to metastatic recurrence. Alternative medicines are thus urgently needed. Cumulative evidence has pointed out that pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene, PS) has excellent pharmacological benefits for the prevention and treatment for various types of cancer in their different stages of progression by evoking apoptotic or nonapoptotic anti-cancer activities. In this review article, we first update current knowledge regarding tumor progression toward accomplishment of metastasis. Subsequently, we review current literature regarding the anti-cancer activities of PS. Finally, we provide future perspectives to clinically utilize PS as novel cancer therapeutic remedies. We, therefore, conclude and propose that PS is one ideal alternative medicine to be administered in the diet as a nutritional supplement. View Full-Text
Keywords: apoptosis; fibronectin; cancer metastasis; pterostilbene apoptosis; fibronectin; cancer metastasis; pterostilbene

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Chen, R.-J.; Kuo, H.-C.; Cheng, L.-H.; Lee, Y.-H.; Chang, W.-T.; Wang, B.-J.; Wang, Y.-J.; Cheng, H.-C. Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer. Int. J. Mol. Sci. 2018, 19, 287.

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