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Int. J. Mol. Sci. 2018, 19(1), 246; https://doi.org/10.3390/ijms19010246

Synergistic Effect of Metal Oxide Nanoparticles on Cell Viability and Activation of MAP Kinases and NFκB

Inmunología, Centro de Investigaciones Biomédicas (CINBIO), Centro Singular de Investigación de Galicia, Instituto de Investigación Sanitaria Galicia Sur (IIS-GS), Universidade de Vigo, Campus Universitario de Vigo, 36310 Pontevedra, Spain
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Received: 20 December 2017 / Revised: 10 January 2018 / Accepted: 11 January 2018 / Published: 15 January 2018
(This article belongs to the Special Issue Nanotoxicology and Nanosafety)
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Abstract

In recent years, there has been an increase in the production of several types of nanoparticles (Nps) for different purposes. Several studies have been performed to analyse the toxicity induced by some of these individual Nps, but data are scarce on the potential hazards or beneficial effects induced by a range of nanomaterials in the same environment. The purpose of the study described here was to evaluate the toxicological effects induced by in vitro exposure of human cells to ZnO Nps in combination with different concentrations of other metal oxide Nps (Al2O3, CeO2, TiO2 and Y2O3). The results indicate that the presence of these Nps has synergistic or antagonistic effects on the cell death induced by ZnO Nps, with a quite marked beneficial effect observed when high concentrations of Nps were tested. Moreover, analysis by Western blot of the main components of the intracellular activation routes (MAPKs and NFκB) again showed that the presence of other Nps can affect cell activation. In conclusion, the presence of several Nps in the same environment modifies the functional activity of one individual Np. Further studies are required in order to elucidate the effects induced by combinations of nanomaterials. View Full-Text
Keywords: nanotoxicity; ion release; accidental exposure; Np combinations; viability; cell activation; ERK; p38; SAPK/JNK; IκBα nanotoxicity; ion release; accidental exposure; Np combinations; viability; cell activation; ERK; p38; SAPK/JNK; IκBα
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Dávila-Grana, Á.; Diego-González, L.; González-Fernández, Á.; Simón-Vázquez, R. Synergistic Effect of Metal Oxide Nanoparticles on Cell Viability and Activation of MAP Kinases and NFκB. Int. J. Mol. Sci. 2018, 19, 246.

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