Next Article in Journal
Pituitary Gonadotropins, Prolactin and Growth Hormone Differentially Regulate AQP1 Expression in the Porcine Ovarian Follicular Cells
Next Article in Special Issue
The Osteogenic Differentiation Effect of the FN Type 10-Peptide Amphiphile on PCL Fiber
Previous Article in Journal
Telomerase Inhibitors from Natural Products and Their Anticancer Potential
Previous Article in Special Issue
Effects and Mechanisms of Total Flavonoids from Blumea balsamifera (L.) DC. on Skin Wound in Rats
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessOpinion

Designing Smart Biomaterials for Tissue Engineering

1,*,† and 1,2,*
Soft-Materials Chemistry, Institute for Materials Chemistry and Engineering, Kyushu University, 744 Motooka Nishi-ku, Fukuoka 819-0395, Japan
Frontier Center for Organic Materials, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan
Authors to whom correspondence should be addressed.
Current address: ECOSE-Biopolymer, Knauf Insulation Limited, P.O. Box 10, Stafford Road, ST. HELENS WA10 3NS, UK.
Int. J. Mol. Sci. 2018, 19(1), 17;
Received: 1 November 2017 / Revised: 30 November 2017 / Accepted: 1 December 2017 / Published: 21 December 2017
(This article belongs to the Special Issue Novel Biomaterials for Tissue Engineering 2018)
PDF [4063 KB, uploaded 21 December 2017]


The engineering of human tissues to cure diseases is an interdisciplinary and a very attractive field of research both in academia and the biotechnology industrial sector. Three-dimensional (3D) biomaterial scaffolds can play a critical role in the development of new tissue morphogenesis via interacting with human cells. Although simple polymeric biomaterials can provide mechanical and physical properties required for tissue development, insufficient biomimetic property and lack of interactions with human progenitor cells remain problematic for the promotion of functional tissue formation. Therefore, the developments of advanced functional biomaterials that respond to stimulus could be the next choice to generate smart 3D biomimetic scaffolds, actively interacting with human stem cells and progenitors along with structural integrity to form functional tissue within a short period. To date, smart biomaterials are designed to interact with biological systems for a wide range of biomedical applications, from the delivery of bioactive molecules and cell adhesion mediators to cellular functioning for the engineering of functional tissues to treat diseases. View Full-Text
Keywords: tissue engineering; smart materials; extracellular matrix; stimuli responsive polymer tissue engineering; smart materials; extracellular matrix; stimuli responsive polymer

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Printed Edition Available!
A printed edition of this Special Issue is available here.

Share & Cite This Article

MDPI and ACS Style

Khan, F.; Tanaka, M. Designing Smart Biomaterials for Tissue Engineering. Int. J. Mol. Sci. 2018, 19, 17.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top