Next Article in Journal
Computational Insights into the Interactions between Calmodulin and the c/nSH2 Domains of p85α Regulatory Subunit of PI3Kα: Implication for PI3Kα Activation by Calmodulin
Next Article in Special Issue
Tissue Engineering to Improve Immature Testicular Tissue and Cell Transplantation Outcomes: One Step Closer to Fertility Restoration for Prepubertal Boys Exposed to Gonadotoxic Treatments
Previous Article in Journal
Implications of Aquaglyceroporin 7 in Energy Metabolism
Previous Article in Special Issue
Designing Smart Biomaterials for Tissue Engineering
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2018, 19(1), 153; https://doi.org/10.3390/ijms19010153

The Osteogenic Differentiation Effect of the FN Type 10-Peptide Amphiphile on PCL Fiber

1
Industrial Technology Research Group, Research and Development Division, World Institute of Kimchi, Nam-Gu, Gwangju 61755, Korea
2
Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Korea
3
Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Korea
4
Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan 330-714, Korea
5
Department of Biochemistry, Inha University School of Medicine, Incheon 22212, Korea
*
Authors to whom correspondence should be addressed.
Received: 1 November 2017 / Revised: 3 January 2018 / Accepted: 3 January 2018 / Published: 4 January 2018
(This article belongs to the Special Issue Novel Biomaterials for Tissue Engineering 2018)
Full-Text   |   PDF [2697 KB, uploaded 4 January 2018]   |  

Abstract

The fibronectin type 10-peptide amphiphile (FNIII10-PA) was previously genetically engineered and showed osteogenic differentiation activity on rat bone marrow stem cells (rBMSCs). In this study, we investigated whether FNIII10-PA demonstrated cellular activity on polycaprolactone (PCL) fibers. FNIII10-PA significantly increased protein production and cell adhesion activity on PCL fibers in a dose-dependent manner. In cell proliferation results, there was no effect on cell proliferation activity by FNIII10-PA; however, FNIII10-PA induced the osteogenic differentiation of MC3T3-E1 cells via upregulation of bone sialoprotein (BSP), collagen type I (Col I), osteocalcin (OC), osteopontin (OPN), and runt-related transcription factor 2 (Runx2) mitochondrial RNA (mRNA) levels; it did not increase the alkaline phosphatase (ALP) mRNA level. These results indicate that FNIII10-PA has potential as a new biomaterial for bone tissue engineering applications. View Full-Text
Keywords: FNIII10; peptide amphiphile; PCL fiber; osteogenic differentiation activity FNIII10; peptide amphiphile; PCL fiber; osteogenic differentiation activity
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Yun, Y.-R.; Kim, H.-W.; Jang, J.-H. The Osteogenic Differentiation Effect of the FN Type 10-Peptide Amphiphile on PCL Fiber. Int. J. Mol. Sci. 2018, 19, 153.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top