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Int. J. Mol. Sci. 2018, 19(1), 148;

Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets

Centre National de la Recherche Scientifique (CNRS), Université Côte d’Azur, Inserm, iBV, 06108 Nice, France
College of Sciences, Biotechnology Department, University of Bagdad, Bagdad, Iraq
Regenerative Medicine and Skeleton. RMeS-Lab, INSERM UMR 1229, University of Nantes, 44000 Nantes, France
Chimie et Interdisciplinarité, Synthèse, Analyse, Modélisation (CEISAM), UMR CNRS 6230, University of Nantes, 44300 Nantes, France
Faculty of Pharmaceutical Sciences, University of Nantes, 44000 Nantes, France
Contributed equally to this manuscript.
Author to whom correspondence should be addressed.
Received: 21 November 2017 / Revised: 22 December 2017 / Accepted: 2 January 2018 / Published: 4 January 2018
(This article belongs to the Special Issue Bone Metastasis: Pathophysiology and Molecular Mechanisms)
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Bone is one of the most preferential target site for cancer metastases, particularly for prostate, breast, kidney, lung and thyroid primary tumours. Indeed, numerous chemical signals and growth factors produced by the bone microenvironment constitute factors promoting cancer cell invasion and aggression. After reviewing the different theories proposed to provide mechanism for metastatic progression, we report on the gene expression profile of bone-seeking cancer cells. We also discuss the cross-talk between the bone microenvironment and invading cells, which impacts on the tumour actions on surrounding bone tissue. Lastly, we detail therapies for bone metastases. Due to poor prognosis for patients, the strategies mainly aim at reducing the impact of skeletal-related events on patients’ quality of life. However, recent advances have led to a better understanding of molecular mechanisms underlying bone metastases progression, and therefore of novel therapeutic targets. View Full-Text
Keywords: bone metastases; bone tropism; bone microenvironment; molecular mechanisms; therapeutic strategies bone metastases; bone tropism; bone microenvironment; molecular mechanisms; therapeutic strategies

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Schmid-Alliana, A.; Schmid-Antomarchi, H.; Al-Sahlanee, R.; Lagadec, P.; Scimeca, J.-C.; Verron, E. Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets. Int. J. Mol. Sci. 2018, 19, 148.

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