MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review
Abstract
:1. Introduction
2. MicroRNAs in Human Soft Tissue Sarcoma
2.1. Liposarcoma
2.2. Leiomyosarcoma
2.3. Synovial Sarcoma
2.4. Malignant Peripheral Nerve Sheath Tumour (MPNST)
2.5. Rhabdomyosaroma
2.6. Fibrosarcoma
2.7. Undifferentiated Pleomorphic Sarcoma (UPS)
2.8. Angiosarcoma
3. Conclusions
Author Contributions
Conflicts of Interest
Abbreviations
3′UTR | 3′-untranslated region |
BCL2 | B-cell lymphoma 2 |
CCND2 | Cyclin D2 |
CDK4 | Cyclin dependent kinase 4 |
CDKN1a | Cyclin-dependent kinase 1 |
CK1α | Casein kinase 1α |
CTX | Chemotherapy |
DNMT1 | DNA (cytosine-5)-methyltransferase-1 |
EGR1 | Early growth response protein 1 |
EZH2 | Enhancer of zeste homolog 2 |
HGF | Hepatocyte growth factor |
HMGA2 | High-mobility group AT-hook 2 |
HOXA5 | Homeobox protein A5 |
IGF1R | Insulin-like growth factor receptor 1 |
KCa3.1 | Potassium intermediate conductance calcium-activated channel |
KPNB1 | Importin subunit beta-1 |
MDM2 | Mouse double minute 2 homolog |
miRNA | Micro RNA |
MMP-2 | Matrix metalloproteinase-2 |
MPNST | Malignant peripheral nerve sheath tumour |
mRNA | Messenger RNA |
mTOR | Mechanistic target of rapamycin |
NF-κb | Kappa-light-chain-enhancer of activated B cells |
PAI-1 | Plasminogen activator inhibitor-1 |
PDCD4 | Programmed cell death protein 4 |
PLK1 | Polo-like-kinase 1 |
PRC1 | Protein regulator of cytokinesis |
PRC2 | Polycomb-repressor complex |
Pre-miRNA | Precursor miRNA |
Pri-miRNA | Primary miRNA |
PTEN | Phosphatase and tensin homolog |
RARE | Retinoic acid response element |
RCBTB1 | Regulator of chromosome condensation and BTB domain-containing protein 1 |
RTX | Radiotherapy |
RXR | Retinoic X receptor |
RXRA | Retinoic X receptor alpha |
SIRT1 | Surtuin 1 |
SMA | Smooth muscle actin |
STS | Soft tissue sarcoma |
THBS1 | Throbmospondin 1 |
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microRNA | Histological Subtype | Expression | Target |
---|---|---|---|
let-7b | Well-/dedifferentiated liposarcoma | Underexpression | |
let-7g | Well-/dedifferentiated liposarcoma | Underexpression | |
miR-1 | Rhabdomyosarcoma | Underexpression | CCND2, PAX3 |
miR-143 | Well-/dedifferentiated liposarcoma Synovial sarcoma | Underexpression | PRC1, PLK1, BCL2 |
miR-145 | Liposarcoma | Underexpression | |
miR-152 | Leiomyosarcoma | Underexpression | MET, KIT |
miR-155 | Myxoid/round cell liposarcoma Dedifferentiated liposarcoma Pleomorphic liposarcoma | Overexpression | CK1α |
miR-17 | Synovial sarcoma | Overexpression | CDKN1A |
miR-183 | Synovial sarcoma | Overexpression | EGR1, PTEN |
Rhabdomyosarcoma | Overexpression | EGR1, PTEN | |
miR-199b-5p | Leiomyosarcoma | Underexpression | |
UPS | Overexpression | ||
miR-206 | Rhabdomyosarcoma | Underexpression | CCND2, PAX3 |
miR-21 | MPNST | Overexpression | PDCD4 |
miR-26a-2 | Liposarcoma | Overexpression | RCBTB1, HOXA5 |
miR-27a | Rhabdomyosarcoma | Overexpression | RARA, RXRA |
miR-29 | Rhabdomyosarcoma | Underexpression | CCND2, PAX3, E2F7 |
Fibrosarcoma | Underexpression | MMP2 | |
miR-29c | MPNST | Underexpression | MMP2 |
miR-30d | MPNST | Underexpression | KPNB1 |
miR-320a | Leiomyosarcoma | Overexpression | |
UPS | Underexpression | ||
miR-34a | MPNST | Underexpression | |
miR-373 | Fibrosarcoma | Overexpression | SIRT1, mTOR |
miR-378a-3p | Rhabdomyosarcoma | Underexpression | IGF1R |
miR-451 | Liposarcoma | Underexpression | |
miR-486 | Myxoid/round cell liposarcoma | Underexpression | PAI-1 |
miR-497-5p | Angiosarcoma | Underexpression | KCa3.1 |
miR-520c | Fibrosarcoma | Overexpression | SIRT1, mTOR |
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Smolle, M.A.; Leithner, A.; Posch, F.; Szkandera, J.; Liegl-Atzwanger, B.; Pichler, M. MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review. Int. J. Mol. Sci. 2017, 18, 1960. https://doi.org/10.3390/ijms18091960
Smolle MA, Leithner A, Posch F, Szkandera J, Liegl-Atzwanger B, Pichler M. MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review. International Journal of Molecular Sciences. 2017; 18(9):1960. https://doi.org/10.3390/ijms18091960
Chicago/Turabian StyleSmolle, Maria Anna, Andreas Leithner, Florian Posch, Joanna Szkandera, Bernadette Liegl-Atzwanger, and Martin Pichler. 2017. "MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review" International Journal of Molecular Sciences 18, no. 9: 1960. https://doi.org/10.3390/ijms18091960