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Open AccessReview

Propolis Diterpenes as a Remarkable Bio-Source for Drug Discovery Development: A Review

Faculty of Pharmacy A15, The University of Sydney, Sydney NSW 2006, Australia
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Int. J. Mol. Sci. 2017, 18(6), 1290; https://doi.org/10.3390/ijms18061290
Received: 26 May 2017 / Revised: 12 June 2017 / Accepted: 15 June 2017 / Published: 17 June 2017
(This article belongs to the Section Bioactives and Nutraceuticals)
Propolis is one of the complex, but valuable, bio-sources for discovering therapeutic compounds. Diterpenes are organic compounds composed of four isoprene units and are known for their biological and pharmacological characteristics, such as antibacterial, anticancer, and anti-inflammatory activities. Recently, advancements have been made in the development of antibacterial and anticancer leads from propolis-isolated diterpenes, and scrutiny of these compounds is being pursued. Thus, this review covers the progress in this arena, with a focus on the chemistry and biological activities of propolis diterpenes. It is anticipated that important information, in a comprehensive and concise manner, will be delivered here for better understanding of natural product drug discovery research. View Full-Text
Keywords: propolis; diterpenes; anticancer; antibacterial; Brazilian propolis; Mediterranean propolis; European propolis propolis; diterpenes; anticancer; antibacterial; Brazilian propolis; Mediterranean propolis; European propolis
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MDPI and ACS Style

Aminimoghadamfarouj, N.; Nematollahi, A. Propolis Diterpenes as a Remarkable Bio-Source for Drug Discovery Development: A Review. Int. J. Mol. Sci. 2017, 18, 1290.

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