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Int. J. Mol. Sci. 2017, 18(5), 992;

Soft-MS and Computational Mapping of Oleuropein

Chemistry and Chemical Technology Department, University of Calabria, P. Bucci 12C, 87036 Rende, Italy
MEMEG, Department of Biology, Lund University, 223 62 Lund, Sweden
DIMEG Department, University of Calabria, P. Bucci 42C, 87036 Rende, Italy
IRESMO Foundation Group, via Petrozza 16A, 87040 Montalto Uffugo, Italy
Department of Engineering Technology, College of Technology, University of Houston, Houston, TX 77204, USA
Author to whom correspondence should be addressed.
Academic Editors: David Arráez-Román and Ana Maria Gómez Caravaca
Received: 4 April 2017 / Revised: 1 May 2017 / Accepted: 2 May 2017 / Published: 6 May 2017
(This article belongs to the Special Issue Analytical Techniques in Plant and Food Analysis)
Full-Text   |   PDF [3202 KB, uploaded 6 May 2017]   |  


Olive oil and table olives are rich sources of biophenols, which provides a unique taste, aroma and potential health benefits. Specifically, green olive drupes are enriched with oleuropein, a bioactive biophenol secoiridoid. Olive oil contains hydrolytic derivatives such as hydroxytyrosol, oleacein and elenolate from oleuropein as well as tyrosol and oleocanthal from ligstroside. Biophenol secoiridoids are categorized by the presence of elenoic acid or its derivatives in their molecular structure. Medical studies suggest that olive biophenol secoiridoids could prevent cancer, obesity, osteoporosis, and neurodegeneration. Therefore, understanding the biomolecular dynamics of oleuropein can potentially improve olive-based functional foods and nutraceuticals. This review provides a critical assessment of oleuropein biomolecular mechanism and computational mapping that could contribute to nutrigenomics. View Full-Text
Keywords: biophenols; β-glucosidase; hydroxytyrosol; olive oil; secoiridoid; table olives; tyrosol biophenols; β-glucosidase; hydroxytyrosol; olive oil; secoiridoid; table olives; tyrosol

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Gentile, L.; Uccella, N.A.; Sivakumar, G. Soft-MS and Computational Mapping of Oleuropein. Int. J. Mol. Sci. 2017, 18, 992.

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