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Int. J. Mol. Sci. 2017, 18(5), 944;

Effect of High Glucose Levels on White Adipose Cells and Adipokines—Fuel for the Fire

Chronic Disease Program, Ottawa Hospital Research Institute, and Departments of Medicine and of Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, ON K1H 8L6, Canada
Academic Editor: Christa Buechler
Received: 17 March 2017 / Revised: 24 April 2017 / Accepted: 26 April 2017 / Published: 29 April 2017
(This article belongs to the Special Issue Adipokines)
Full-Text   |   PDF [178 KB, uploaded 4 May 2017]


White adipocytes release adipokines that influence metabolic and vascular health. Hypertrophic obesity is associated with adipose tissue malfunctioning, leading to inflammation and insulin resistance. When pancreatic islet β cells can no longer compensate, the blood glucose concentration rises (hyperglycemia), resulting in type 2 diabetes. Hyperglycaemia may further aggravate adipose cell dysfunction in ~90% of patients with type 2 diabetes who are obese or overweight. This review will focus on the effects of high glucose levels on human adipose cells and the regulation of adipokines. View Full-Text
Keywords: adipocytes; hyperglycaemia; adipokines adipocytes; hyperglycaemia; adipokines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Sorisky, A. Effect of High Glucose Levels on White Adipose Cells and Adipokines—Fuel for the Fire. Int. J. Mol. Sci. 2017, 18, 944.

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