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Int. J. Mol. Sci. 2017, 18(5), 1079;

[18F]-Fluorinated Carboplatin and [111In]-Liposome for Image-Guided Drug Delivery

Center for Molecular Imaging, Department of Radiology, Virginia Commonwealth University, 1101 E. Marshall Street, Richmond, VA 23298-0031, USA
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 6 March 2017 / Revised: 2 May 2017 / Accepted: 8 May 2017 / Published: 18 May 2017
(This article belongs to the Special Issue Cancer Molecular Imaging in the Era of Precision Medicine)
Full-Text   |   PDF [2387 KB, uploaded 18 May 2017]   |  


Radiolabeled liposomes have been employed as diagnostic tools to monitor in vivo distribution of liposomes in real-time, which helps in optimizing the therapeutic efficacy of the liposomal drug delivery. This work utilizes the platform of [111In]-Liposome as a drug delivery vehicle, encapsulating a novel 18F-labeled carboplatin drug derivative ([18F]-FCP) as a dual-molecular imaging tool as both a radiolabeled drug and radiolabeled carrier. The approach has the potential for clinical translation in individual patients using a dual modal approach of clinically-relevant radionuclides of 18F positron emission tomography (PET) and 111In single photon emission computed tomography (SPECT). [111In]-Liposome was synthesized and evaluated in vivo by biodistribution and SPECT imaging. The [18F]-FCP encapsulated [111In]-Liposome nano-construct was investigated, in vivo, using an optimized dual-tracer PET and SPECT imaging in a nude mouse. The biodistribution data and SPECT imaging showed spleen and liver uptake of [111In]-Liposome and the subsequent clearance of activity with time. Dual-modality imaging of [18F]-FCP encapsulated [111In]-Liposome showed significant uptake in liver and spleen in both PET and SPECT images. Qualitative analysis of SPECT images and quantitative analysis of PET images showed the same pattern of activity during the imaging period and demonstrated the feasibility of dual-tracer imaging of a single dual-labeled nano-construct. View Full-Text
Keywords: radiolabeled liposomes; radiolabeled platinum; drug delivery; dual modality imaging; PET; SPECT radiolabeled liposomes; radiolabeled platinum; drug delivery; dual modality imaging; PET; SPECT

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Lamichhane, N.; Dewkar, G.K.; Sundaresan, G.; Mahon, R.N.; Zweit, J. [18F]-Fluorinated Carboplatin and [111In]-Liposome for Image-Guided Drug Delivery. Int. J. Mol. Sci. 2017, 18, 1079.

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