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Int. J. Mol. Sci. 2017, 18(5), 1066;

dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster

Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali (DiSTeBA)—University of Salento, 73100 Lecce, Italy
Author to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 1 March 2017 / Revised: 9 May 2017 / Accepted: 10 May 2017 / Published: 16 May 2017
(This article belongs to the Collection Regulation by Non-Coding RNAs)
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Fragile-X syndrome is the most common form of inherited mental retardation accompanied by other phenotypes, including macroorchidism. The disorder originates with mutations in the Fmr1 gene coding for the FMRP protein, which, with its paralogs FXR1 and FXR2, constitute a well-conserved family of RNA-binding proteins. Drosophila melanogaster is a good model for the syndrome because it has a unique fragile X-related gene: dFmr1. Recently, in addition to its confirmed role in the miRNA pathway, a function for dFmr1 in the piRNA pathway, operating in Drosophila gonads, has been established. In this review we report a summary of the piRNA pathways occurring in gonads with a special emphasis on the relationship between the piRNA genes and the crystal-Stellate system; we also analyze the roles of dFmr1 in the Drosophila gonads, exploring their genetic and biochemical interactions to reveal some unexpected connections. View Full-Text
Keywords: FMRP/dFmr1; fragile-X syndrome; piRNA pathway; crystal-Stellate system; dFmr1 interactors FMRP/dFmr1; fragile-X syndrome; piRNA pathway; crystal-Stellate system; dFmr1 interactors

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Specchia, V.; D’Attis, S.; Puricella, A.; Bozzetti, M.P. dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster. Int. J. Mol. Sci. 2017, 18, 1066.

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