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Int. J. Mol. Sci. 2017, 18(12), 2693; https://doi.org/10.3390/ijms18122693

The Role of Aquaporins in Ocular Lens Homeostasis

1
Department of Biochemistry, Vanderbilt University, Nashville, TN 37240, USA
2
Department of Physiology, School of Medical Sciences, New Zealand National Eye Centre, University of Auckland, Auckland 1023, New Zealand
3
School of Optometry and Vison Sciences, New Zealand National Eye Centre, University of Auckland, Auckland 1023, New Zealand
*
Author to whom correspondence should be addressed.
Received: 10 November 2017 / Revised: 8 December 2017 / Accepted: 8 December 2017 / Published: 12 December 2017
(This article belongs to the Special Issue Aquaporins: Water Channels Essential for Living Organisms)
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Abstract

Abstract: Aquaporins (AQPs), by playing essential roles in the maintenance of ocular lens homeostasis, contribute to the establishment and maintenance of the overall optical properties of the lens over many decades of life. Three aquaporins, AQP0, AQP1 and AQP5, each with distinctly different functional properties, are abundantly and differentially expressed in the different regions of the ocular lens. Furthermore, the diversity of AQP functionality is increased in the absence of protein turnover by age-related modifications to lens AQPs that are proposed to alter AQP function in the different regions of the lens. These regional differences in AQP functionality are proposed to contribute to the generation and directionality of the lens internal microcirculation; a system of circulating ionic and fluid fluxes that delivers nutrients to and removes wastes from the lens faster than could be achieved by passive diffusion alone. In this review, we present how regional differences in lens AQP isoforms potentially contribute to this microcirculation system by highlighting current areas of investigation and emphasizing areas where future work is required. View Full-Text
Keywords: microcirculation; hydrostatic pressure; regulation; post-translational modification microcirculation; hydrostatic pressure; regulation; post-translational modification
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Schey, K.L.; Petrova, R.S.; Gletten, R.B.; Donaldson, P.J. The Role of Aquaporins in Ocular Lens Homeostasis. Int. J. Mol. Sci. 2017, 18, 2693.

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