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The Genetic Basis of Psoriasis
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Int. J. Mol. Sci. 2017, 18(12), 2650;

The Immunogenetics of Psoriasis and Implications for Drug Repositioning

Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China
Author to whom correspondence should be addressed.
Received: 31 October 2017 / Revised: 22 November 2017 / Accepted: 4 December 2017 / Published: 8 December 2017
(This article belongs to the Special Issue Psoriasis)
Full-Text   |   PDF [246 KB, uploaded 8 December 2017]


Psoriasis is a genetically-regulated, T lymphocyte-mediated autoimmune skin disease that causes systemic damage, seriously affecting patient quality of life and survival. Psoriasis treatments, which aim to control the disease’s development, are greatly limited because its etiology and pathogenesis have not yet been fully elucidated. A large number of studies have demonstrated that immunogenetic elements are the most important factors responsible for psoriasis susceptibility. This paper delineates the immunogenetic mechanisms of psoriasis and provides useful information with regards to performing drug repositioning for the treatment of psoriasis. View Full-Text
Keywords: psoriasis; immunogenetics; genetics; susceptible genes; drug repositioning psoriasis; immunogenetics; genetics; susceptible genes; drug repositioning
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Xu, X.; Zhang, H.-Y. The Immunogenetics of Psoriasis and Implications for Drug Repositioning. Int. J. Mol. Sci. 2017, 18, 2650.

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