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Volume 18
Issue 12
10.3390/ijms18122524
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Review

The POZ/BTB and AT-Hook Containing Zinc Finger 1 (PATZ1) Transcription Regulator: Physiological Functions and Disease Involvement

by
Monica Fedele
*,
Elvira Crescenzi
and
Laura Cerchia
CNR—Institute of Experimental Endocrinology and Oncology (IEOS), 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(12), 2524; https://doi.org/10.3390/ijms18122524
Submission received: 3 November 2017 / Revised: 21 November 2017 / Accepted: 22 November 2017 / Published: 24 November 2017
(This article belongs to the Section Biochemistry)
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Abstract

PATZ1 is a zinc finger protein, belonging to the POZ domain Krüppel-like zinc finger (POK) family of architectural transcription factors, first discovered in 2000 by three independent groups. Since that time accumulating evidences have shown its involvement in a variety of biological processes (i.e., embryogenesis, stemness, apoptosis, senescence, proliferation, T-lymphocyte differentiation) and human diseases. Here we summarize these studies with a focus on the PATZ1 emerging and controversial role in cancer, where it acts as either a tumor suppressor or an oncogene. Finally, we give some insight on clinical perspectives using PATZ1 as a prognostic marker and therapeutic target.
Keywords: PATZ1; chromatin regulator; cancer; biomarker; stem cells PATZ1; chromatin regulator; cancer; biomarker; stem cells

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MDPI and ACS Style

Fedele, M.; Crescenzi, E.; Cerchia, L. The POZ/BTB and AT-Hook Containing Zinc Finger 1 (PATZ1) Transcription Regulator: Physiological Functions and Disease Involvement. Int. J. Mol. Sci. 2017, 18, 2524. https://doi.org/10.3390/ijms18122524

AMA Style

Fedele M, Crescenzi E, Cerchia L. The POZ/BTB and AT-Hook Containing Zinc Finger 1 (PATZ1) Transcription Regulator: Physiological Functions and Disease Involvement. International Journal of Molecular Sciences. 2017; 18(12):2524. https://doi.org/10.3390/ijms18122524

Chicago/Turabian Style

Fedele, Monica, Elvira Crescenzi, and Laura Cerchia. 2017. "The POZ/BTB and AT-Hook Containing Zinc Finger 1 (PATZ1) Transcription Regulator: Physiological Functions and Disease Involvement" International Journal of Molecular Sciences 18, no. 12: 2524. https://doi.org/10.3390/ijms18122524

APA Style

Fedele, M., Crescenzi, E., & Cerchia, L. (2017). The POZ/BTB and AT-Hook Containing Zinc Finger 1 (PATZ1) Transcription Regulator: Physiological Functions and Disease Involvement. International Journal of Molecular Sciences, 18(12), 2524. https://doi.org/10.3390/ijms18122524

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