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Int. J. Mol. Sci. 2017, 18(12), 2524;

The POZ/BTB and AT-Hook Containing Zinc Finger 1 (PATZ1) Transcription Regulator: Physiological Functions and Disease Involvement

CNR—Institute of Experimental Endocrinology and Oncology (IEOS), 80131 Naples, Italy
Author to whom correspondence should be addressed.
Received: 3 November 2017 / Revised: 21 November 2017 / Accepted: 22 November 2017 / Published: 24 November 2017
(This article belongs to the Section Biochemistry)
Full-Text   |   PDF [1127 KB, uploaded 25 November 2017]   |  


PATZ1 is a zinc finger protein, belonging to the POZ domain Krüppel-like zinc finger (POK) family of architectural transcription factors, first discovered in 2000 by three independent groups. Since that time accumulating evidences have shown its involvement in a variety of biological processes (i.e., embryogenesis, stemness, apoptosis, senescence, proliferation, T-lymphocyte differentiation) and human diseases. Here we summarize these studies with a focus on the PATZ1 emerging and controversial role in cancer, where it acts as either a tumor suppressor or an oncogene. Finally, we give some insight on clinical perspectives using PATZ1 as a prognostic marker and therapeutic target. View Full-Text
Keywords: PATZ1; chromatin regulator; cancer; biomarker; stem cells PATZ1; chromatin regulator; cancer; biomarker; stem cells

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Fedele, M.; Crescenzi, E.; Cerchia, L. The POZ/BTB and AT-Hook Containing Zinc Finger 1 (PATZ1) Transcription Regulator: Physiological Functions and Disease Involvement. Int. J. Mol. Sci. 2017, 18, 2524.

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