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Volume 18
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10.3390/ijms18112479
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Article

Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase

by
Takashi Kikuchi
1,
Naoki Motoyashiki
1,
Takeshi Yamada
1,
Kanae Shibatani
2,
Kiyofumi Ninomiya
2,
Toshio Morikawa
2,* and
Reiko Tanaka
1,*
1
Faculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
2
Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(11), 2479; https://doi.org/10.3390/ijms18112479
Submission received: 18 October 2017 / Revised: 13 November 2017 / Accepted: 16 November 2017 / Published: 21 November 2017
(This article belongs to the Special Issue The Molecular Aspect of Natural Secondary Metabolite Products in Health and Disease)
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Abstract

Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3–10). All isolated compounds were evaluated for their inhibitory effects on aromatase. Among them, 4 and 6 exhibited comparable aromatase inhibitory activities to aminoglutethimide.
Keywords: Pleurotus eryngii; sterol; ergostane; aromatase inhibitor Pleurotus eryngii; sterol; ergostane; aromatase inhibitor
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MDPI and ACS Style

Kikuchi, T.; Motoyashiki, N.; Yamada, T.; Shibatani, K.; Ninomiya, K.; Morikawa, T.; Tanaka, R. Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase. Int. J. Mol. Sci. 2017, 18, 2479. https://doi.org/10.3390/ijms18112479

AMA Style

Kikuchi T, Motoyashiki N, Yamada T, Shibatani K, Ninomiya K, Morikawa T, Tanaka R. Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase. International Journal of Molecular Sciences. 2017; 18(11):2479. https://doi.org/10.3390/ijms18112479

Chicago/Turabian Style

Kikuchi, Takashi, Naoki Motoyashiki, Takeshi Yamada, Kanae Shibatani, Kiyofumi Ninomiya, Toshio Morikawa, and Reiko Tanaka. 2017. "Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase" International Journal of Molecular Sciences 18, no. 11: 2479. https://doi.org/10.3390/ijms18112479

APA Style

Kikuchi, T., Motoyashiki, N., Yamada, T., Shibatani, K., Ninomiya, K., Morikawa, T., & Tanaka, R. (2017). Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase. International Journal of Molecular Sciences, 18(11), 2479. https://doi.org/10.3390/ijms18112479

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