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Communication

Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles

Supramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry, Einsteinweg 55, 2333 CC Leiden, The Netherlands
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Int. J. Mol. Sci. 2017, 18(10), 2033; https://doi.org/10.3390/ijms18102033
Received: 30 August 2017 / Revised: 14 September 2017 / Accepted: 18 September 2017 / Published: 22 September 2017
(This article belongs to the Special Issue Nanotechnology in Drug Delivery)
In the treatment of cancer, targeting of anticancer drugs to the tumor microenvironment is highly desirable. Not only does this imply accurate tumor targeting but also minimal drug release en route to the tumor and maximal drug release once there. Here we describe high-loading, “stealth-like” doxorubicin micelles as a pro-drug delivery system, which upon light activation, leads to burst-like doxorbicin release. Through this approach, we show precise spatiotemporal control of doxorubicin delivery to cells in vitro. View Full-Text
Keywords: micelles; prodrugs; doxorubicin; light activation micelles; prodrugs; doxorubicin; light activation
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MDPI and ACS Style

Kong, L.; Poulcharidis, D.; Schneider, G.F.; Campbell, F.; Kros, A. Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles. Int. J. Mol. Sci. 2017, 18, 2033. https://doi.org/10.3390/ijms18102033

AMA Style

Kong L, Poulcharidis D, Schneider GF, Campbell F, Kros A. Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles. International Journal of Molecular Sciences. 2017; 18(10):2033. https://doi.org/10.3390/ijms18102033

Chicago/Turabian Style

Kong, Li, Dimitrios Poulcharidis, Gregory F. Schneider, Frederick Campbell, and Alexander Kros. 2017. "Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles" International Journal of Molecular Sciences 18, no. 10: 2033. https://doi.org/10.3390/ijms18102033

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