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Int. J. Mol. Sci. 2017, 18(1), 56;

Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives

Centre for Applied Biomedical Research (CRBA), S. Orsola-Malpighi University Hospital, 40138 Bologna, Italy
Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
Author to whom correspondence should be addressed.
Academic Editor: Akihiro Tamori
Received: 29 September 2016 / Revised: 12 December 2016 / Accepted: 16 December 2016 / Published: 28 December 2016
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Full-Text   |   PDF [1030 KB, uploaded 28 December 2016]   |  


The Notch signaling pathway is a very conserved system that controls embryonic cell fate decisions and the maintenance of adult stem cells through cell to cell communication. Accumulating evidence support the relevance of Notch signaling in different human diseases and it is one of the most commonly activated signaling pathways in cancer. This review focuses mainly on the role of Notch3 signaling in hepatocellular carcinoma and its potential therapeutic applications against this malignancy. In this regard, the crosstalk between Notch and p53 may play an important role. View Full-Text
Keywords: Notch; p53; hepatocellular carcinoma (HCC) Notch; p53; hepatocellular carcinoma (HCC)

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Giovannini, C.; Bolondi, L.; Gramantieri, L. Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives. Int. J. Mol. Sci. 2017, 18, 56.

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