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Int. J. Mol. Sci. 2017, 18(1), 14;

Calcium-Mediated Control of Polydopamine Film Oxidation and Iron Chelation

Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Author to whom correspondence should be addressed.
Academic Editor: Marco d’Ischia
Received: 29 November 2016 / Revised: 15 December 2016 / Accepted: 19 December 2016 / Published: 22 December 2016
(This article belongs to the Special Issue Melanin Based Functional Materials)
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The facile preparation of conformal polydopamine (PDA) films on broad classes of materials has prompted extensive research into a wide variety of potential applications for PDA. The constituent molecular species in PDA exhibit diverse chemical moieties, and therefore highly variable properties of PDA-based devices may evolve with post-processing conditions. Here we report the use of redox-inactive cations for oxidative post-processing of deposited PDA films. PDA films incubated in alkaline CaCl2 solutions exhibit accelerated oxidative evolution in a dose-dependent manner. PDA films incubated in CaCl2 solutions exhibit 53% of the oxidative charge transfer compared to pristine PDA films. Carboxylic acid groups generated from the oxidation process lower the isoelectric point of PDA films from pH = 4.0 ± 0.2 to pH = 3.1 ± 0.3. PDA films exposed to CaCl2 solutions during post-processing also enhance Fe2+/Fe3+ chelation compared to pristine PDA films. These data illustrate that the molecular heterogeneity and non-equilibrium character of as-deposited PDA films afford control over the final composition by choosing post-processing conditions, but also demands forethought into how the performance of PDA-incorporated devices may change over time in salt solutions. View Full-Text
Keywords: polydopamine; melanin; thin film; metal cation; dopamine oxidation polydopamine; melanin; thin film; metal cation; dopamine oxidation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Klosterman, L.; Bettinger, C.J. Calcium-Mediated Control of Polydopamine Film Oxidation and Iron Chelation. Int. J. Mol. Sci. 2017, 18, 14.

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