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Int. J. Mol. Sci. 2016, 17(7), 1081;

Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine

Laboratory for Metabolic Signaling, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan
Author to whom correspondence should be addressed.
Academic Editor: Gopinadhan Paliyath
Received: 28 May 2016 / Revised: 21 June 2016 / Accepted: 30 June 2016 / Published: 7 July 2016
(This article belongs to the Special Issue The Mechanism of Action of Food Components in Disease Prevention)
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Obesity causes a significant negative impact on health of human beings world-wide. The main reason for weight gain, which eventually leads to obesity, is excessive ingestion of energy above the body’s homeostatic needs. Therefore, the elucidation of detailed mechanisms for appetite control is necessary to prevent and treat obesity. N-methyl-d-aspartate (NMDA) receptor is a post-synaptic glutamate receptor and is important for excitatory neurotransmission. It is expressed throughout the nervous system, and is important for long-term potentiation. It requires both ligand (glutamate) and co-agonist (d-serine or glycine) for efficient opening of the channel to allow calcium influx. d-serine is contained in fermented foods and marine invertebrates, and brain d-serine level is maintained by synthesis in vivo and supply from food and gut microbiota. Although the NMDA receptor has been reported to take part in the central regulation of appetite, the role of d-serine had not been addressed. We recently reported that exogenous d-serine administration can suppress appetite and alter food preference. In this review, we will discuss how NMDA receptor and its co-agonist d-seine participate in the control of appetite and food preference, and elaborate on how this system could possibly be manipulated to suppress obesity. View Full-Text
Keywords: anorexia; appetite; D-serine; food preference; hyperphagia; NMDA receptor anorexia; appetite; D-serine; food preference; hyperphagia; NMDA receptor

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Sasaki, T.; Matsui, S.; Kitamura, T. Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine. Int. J. Mol. Sci. 2016, 17, 1081.

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