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Nutrigenomics and Beef Quality: A Review about Lipogenesis

Department of Animal Science, Universidade Federal de Lavras, Lavras 37200-000, Brazil
Department of Animal Science, Purdue University, West Lafayette, IN 47906, USA
Author to whom correspondence should be addressed.
Academic Editors: Marcello Iriti and Alejandro Cifuentes
Int. J. Mol. Sci. 2016, 17(6), 918;
Received: 29 January 2016 / Revised: 6 May 2016 / Accepted: 17 May 2016 / Published: 10 June 2016
(This article belongs to the Special Issue Nutrigenetics and Nutrigenomics)
The objective of the present review is to discuss the results of published studies that show how nutrition affects the expression of genes involved in lipid metabolism and how diet manipulation might change marbling and composition of fat in beef. Several key points in the synthesis of fat in cattle take place at the molecular level, and the association of nutritional factors with the modulation of this metabolism is one of the recent targets of nutrigenomic research. Within this context, special attention has been paid to the study of nuclear receptors associated with fatty acid metabolism. Among the transcription factors involved in lipid metabolism, the peroxisome proliferator-activated receptors (PPARs) and sterol regulatory element-binding proteins (SREBPs) stand out. The mRNA synthesis of these transcription factors is regulated by nutrients, and their metabolic action might be potentiated by diet components and change lipogenesis in muscle. Among the options for dietary manipulation with the objective to modulate lipogenesis, the use of different sources of polyunsaturated fatty acids, starch concentrations, forage ratios and vitamins stand out. Therefore, special care must be exercised in feedlot feed management, mainly when the goal is to produce high marbling beef. View Full-Text
Keywords: gene expression; transcription factors; lipogenesis; PPAR; SREBF1 gene expression; transcription factors; lipogenesis; PPAR; SREBF1
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MDPI and ACS Style

Ladeira, M.M.; Schoonmaker, J.P.; Gionbelli, M.P.; Dias, J.C.O.; Gionbelli, T.R.S.; Carvalho, J.R.R.; Teixeira, P.D. Nutrigenomics and Beef Quality: A Review about Lipogenesis. Int. J. Mol. Sci. 2016, 17, 918.

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