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Open AccessArticle

Impact of Lipoprotein Lipase Gene Polymorphism, S447X, on Postprandial Triacylglycerol and Glucose Response to Sequential Meal Ingestion

1
Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK
2
Food and Nutrition Department, Faculty of Home Economics, King Abdulaziz University, Jeddah 21589, Saudi Arabia
3
Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
4
Institute for Cardiovascular and Metabolic Research (ICMR), University of Reading, Reading RG6 6AS, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Int. J. Mol. Sci. 2016, 17(3), 397; https://doi.org/10.3390/ijms17030397
Received: 3 February 2016 / Revised: 7 March 2016 / Accepted: 9 March 2016 / Published: 18 March 2016
(This article belongs to the Special Issue Nutrigenetics and Nutrigenomics)
Lipoprotein lipase (LPL) is a key rate-limiting enzyme for the hydrolysis of triacylglycerol (TAG) in chylomicrons and very low-density lipoprotein. Given that postprandial assessment of lipoprotein metabolism may provide a more physiological perspective of disturbances in lipoprotein homeostasis compared to assessment in the fasting state, we have investigated the influence of two commonly studied LPL polymorphisms (rs320, HindIII; rs328, S447X) on postprandial lipaemia, in 261 participants using a standard sequential meal challenge. S447 homozygotes had lower fasting HDL-C (p = 0.015) and a trend for higher fasting TAG (p = 0.057) concentrations relative to the 447X allele carriers. In the postprandial state, there was an association of the S447X polymorphism with postprandial TAG and glucose, where S447 homozygotes had 12% higher TAG area under the curve (AUC) (p = 0.037), 8.4% higher glucose-AUC (p = 0.006) and 22% higher glucose-incremental area under the curve (IAUC) (p = 0.042). A significant gene–gender interaction was observed for fasting TAG (p = 0.004), TAG-AUC (Pinteraction = 0.004) and TAG-IAUC (Pinteraction = 0.016), where associations were only evident in men. In conclusion, our study provides novel findings of an effect of LPL S447X polymorphism on the postprandial glucose and gender-specific impact of the polymorphism on fasting and postprandial TAG concentrations in response to sequential meal challenge in healthy participants. View Full-Text
Keywords: lipoprotein lipase; sequential meals; postprandial study; triacylglycerol; glucose lipoprotein lipase; sequential meals; postprandial study; triacylglycerol; glucose
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MDPI and ACS Style

Shatwan, I.M.; Minihane, A.-M.; Williams, C.M.; Lovegrove, J.A.; Jackson, K.G.; Vimaleswaran, K.S. Impact of Lipoprotein Lipase Gene Polymorphism, S447X, on Postprandial Triacylglycerol and Glucose Response to Sequential Meal Ingestion. Int. J. Mol. Sci. 2016, 17, 397.

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