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Int. J. Mol. Sci. 2016, 17(3), 397;

Impact of Lipoprotein Lipase Gene Polymorphism, S447X, on Postprandial Triacylglycerol and Glucose Response to Sequential Meal Ingestion

Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK
Food and Nutrition Department, Faculty of Home Economics, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
Institute for Cardiovascular and Metabolic Research (ICMR), University of Reading, Reading RG6 6AS, UK
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 3 February 2016 / Revised: 7 March 2016 / Accepted: 9 March 2016 / Published: 18 March 2016
(This article belongs to the Special Issue Nutrigenetics and Nutrigenomics)
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Lipoprotein lipase (LPL) is a key rate-limiting enzyme for the hydrolysis of triacylglycerol (TAG) in chylomicrons and very low-density lipoprotein. Given that postprandial assessment of lipoprotein metabolism may provide a more physiological perspective of disturbances in lipoprotein homeostasis compared to assessment in the fasting state, we have investigated the influence of two commonly studied LPL polymorphisms (rs320, HindIII; rs328, S447X) on postprandial lipaemia, in 261 participants using a standard sequential meal challenge. S447 homozygotes had lower fasting HDL-C (p = 0.015) and a trend for higher fasting TAG (p = 0.057) concentrations relative to the 447X allele carriers. In the postprandial state, there was an association of the S447X polymorphism with postprandial TAG and glucose, where S447 homozygotes had 12% higher TAG area under the curve (AUC) (p = 0.037), 8.4% higher glucose-AUC (p = 0.006) and 22% higher glucose-incremental area under the curve (IAUC) (p = 0.042). A significant gene–gender interaction was observed for fasting TAG (p = 0.004), TAG-AUC (Pinteraction = 0.004) and TAG-IAUC (Pinteraction = 0.016), where associations were only evident in men. In conclusion, our study provides novel findings of an effect of LPL S447X polymorphism on the postprandial glucose and gender-specific impact of the polymorphism on fasting and postprandial TAG concentrations in response to sequential meal challenge in healthy participants. View Full-Text
Keywords: lipoprotein lipase; sequential meals; postprandial study; triacylglycerol; glucose lipoprotein lipase; sequential meals; postprandial study; triacylglycerol; glucose

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Shatwan, I.M.; Minihane, A.-M.; Williams, C.M.; Lovegrove, J.A.; Jackson, K.G.; Vimaleswaran, K.S. Impact of Lipoprotein Lipase Gene Polymorphism, S447X, on Postprandial Triacylglycerol and Glucose Response to Sequential Meal Ingestion. Int. J. Mol. Sci. 2016, 17, 397.

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