Next Article in Journal
Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR)
Next Article in Special Issue
Programming Effects of Prenatal Glucocorticoid Exposure with a Postnatal High-Fat Diet in Diabetes Mellitus
Previous Article in Journal / Special Issue
MicroRNAs in Hyperglycemia Induced Endothelial Cell Dysfunction
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 17
Issue 4
10.3390/ijms17040522
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Interleukin-17A Differentially Induces Inflammatory and Metabolic Gene Expression in the Adipose Tissues of Lean and Obese Mice

by
Yine Qu
1,2,
Qiuyang Zhang
1,
Siqi Ma
2,
Sen Liu
1,
Zhiquan Chen
1,3,
Zhongfu Mo
1,4 and
Zongbing You
1,5,6,7,8,*
1
Department of Structural and Cellular Biology, Tulane University, New Orleans, LA 70112, USA
2
Department of Histology and Embryology, School of Basic Medicine of North China University of Science and Technology, Tangshan 063000, China
3
Department of Thoracic Surgery, Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, China
4
Department of Obstetrics and Gynecology, Shijiazhuang Maternal and Child Health Care Hospital, Shijiazhuang 050000, China
5
Department of Orthopaedic Surgery, Tulane University, New Orleans, LA 70112, USA
6
Tulane Cancer Center and Louisiana Cancer Research Consortium, Tulane University, New Orleans, LA 70112, USA
7
Tulane Center for Stem Cell Research and Regenerative Medicine, Tulane University, New Orleans, LA 70112, USA
8
Tulane Center for Aging, Tulane University, New Orleans, LA 70112, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2016, 17(4), 522; https://doi.org/10.3390/ijms17040522
Submission received: 11 February 2016 / Revised: 17 March 2016 / Accepted: 30 March 2016 / Published: 7 April 2016
(This article belongs to the Special Issue Molecular Research on Obesity and Diabetes)
Browse Figures
Versions Notes

Abstract

The functions of interleukin-17A (IL-17A) in adipose tissues and adipocytes have not been well understood. In the present study, male mice were fed with a regular diet (n = 6, lean mice) or a high-fat diet (n = 6, obese mice) for 30 weeks. Subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were analyzed for IL-17A levels. SAT and VAT were treated with IL-17A and analyzed for inflammatory and metabolic gene expression. Mouse 3T3-L1 pre-adipocytes were differentiated into adipocytes, followed with IL-17A treatment and analysis for inflammatory and metabolic gene expression. We found that IL-17A levels were higher in obese SAT than lean SAT; the basal expression of inflammatory and metabolic genes was different between SAT and VAT and between lean and obese adipose tissues. IL-17A differentially induced expression of inflammatory and metabolic genes, such as tumor necrosis factor α, Il-6, Il-1β, leptin, and glucose transporter 4, in adipose tissues of lean and obese mice. IL-17A also differentially induced expression of inflammatory and metabolic genes in pre-adipocytes and adipocytes, and IL-17A selectively activated signaling pathways in adipose tissues and adipocytes. These findings suggest that IL-17A differentially induces inflammatory and metabolic gene expression in the adipose tissues of lean and obese mice.
Keywords: interleukin-17A; inflammation; metabolism; obesity; gene expression interleukin-17A; inflammation; metabolism; obesity; gene expression
Graphical Abstract

Share and Cite

MDPI and ACS Style

Qu, Y.; Zhang, Q.; Ma, S.; Liu, S.; Chen, Z.; Mo, Z.; You, Z. Interleukin-17A Differentially Induces Inflammatory and Metabolic Gene Expression in the Adipose Tissues of Lean and Obese Mice. Int. J. Mol. Sci. 2016, 17, 522. https://doi.org/10.3390/ijms17040522

AMA Style

Qu Y, Zhang Q, Ma S, Liu S, Chen Z, Mo Z, You Z. Interleukin-17A Differentially Induces Inflammatory and Metabolic Gene Expression in the Adipose Tissues of Lean and Obese Mice. International Journal of Molecular Sciences. 2016; 17(4):522. https://doi.org/10.3390/ijms17040522

Chicago/Turabian Style

Qu, Yine, Qiuyang Zhang, Siqi Ma, Sen Liu, Zhiquan Chen, Zhongfu Mo, and Zongbing You. 2016. "Interleukin-17A Differentially Induces Inflammatory and Metabolic Gene Expression in the Adipose Tissues of Lean and Obese Mice" International Journal of Molecular Sciences 17, no. 4: 522. https://doi.org/10.3390/ijms17040522

APA Style

Qu, Y., Zhang, Q., Ma, S., Liu, S., Chen, Z., Mo, Z., & You, Z. (2016). Interleukin-17A Differentially Induces Inflammatory and Metabolic Gene Expression in the Adipose Tissues of Lean and Obese Mice. International Journal of Molecular Sciences, 17(4), 522. https://doi.org/10.3390/ijms17040522

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop