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Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA
Author to whom correspondence should be addressed.
Academic Editor: Kurt A. Jellinger
Int. J. Mol. Sci. 2016, 17(3), 338;
Received: 19 December 2015 / Revised: 14 February 2016 / Accepted: 24 February 2016 / Published: 4 March 2016
(This article belongs to the Special Issue Amyloid-beta and Neurological Diseases)
PDF [262 KB, uploaded 4 March 2016]


Amyloid-β (Aβ) pathology is known to promote chronic inflammatory responses in the brain. It was thought previously that Aβ is only associated with Alzheimer’s disease and Down syndrome. However, studies have shown its involvement in many other neurological disorders. The role of astrocytes in handling the excess levels of Aβ has been highlighted in the literature. Astrocytes have a distinctive function in both neuronal support and protection, thus its involvement in Aβ pathological process may tip the balance toward chronic inflammation and neuronal death. In this review we describe the involvement of astrocytes in Aβ related disorders including Alzheimer’s disease, Down syndrome, cerebral amyloid angiopathy, and frontotemporal dementia. View Full-Text
Keywords: Alzheimer’s disease; cerebral amyloid angiopathy; Down syndrome; frontotemporal dementia; astrocytes; Amyloid-β Alzheimer’s disease; cerebral amyloid angiopathy; Down syndrome; frontotemporal dementia; astrocytes; Amyloid-β

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Batarseh, Y.S.; Duong, Q.-V.; Mousa, Y.M.; Al Rihani, S.B.; Elfakhri, K.; Kaddoumi, A. Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders. Int. J. Mol. Sci. 2016, 17, 338.

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