Hepatotoxicity by Drugs: The Most Common Implicated Agents
Department of Internal Medicine, Division of Gastroenterology and Hepatology, The National University Hospital of Iceland and The Faculty of Medicine, The University of Iceland, 108 Reykjavik, Iceland
Int. J. Mol. Sci. 2016, 17(2), 224; https://doi.org/10.3390/ijms17020224
Received: 4 January 2016 / Revised: 28 January 2016 / Accepted: 1 February 2016 / Published: 6 February 2016
(This article belongs to the Special Issue Drug, Herb, and Dietary Supplement Hepatotoxicity)
Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury. Only 48 drugs had more than 50 case reports of DILI. Amoxicillin-clavulanate is the most commonly implicated agent leading to DILI in the prospective series. In a recent prospective study, liver injury due to amoxicillin-clavulanate was found to occur in approximately one out of 2300 users. Drugs with the highest risk of DILI in this study were azathioprine and infliximab.
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Keywords:
hepatotoxicity; drugs; drug-induced liver injury; idiosyncratic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Björnsson, E.S. Hepatotoxicity by Drugs: The Most Common Implicated Agents. Int. J. Mol. Sci. 2016, 17, 224. https://doi.org/10.3390/ijms17020224
AMA Style
Björnsson ES. Hepatotoxicity by Drugs: The Most Common Implicated Agents. International Journal of Molecular Sciences. 2016; 17(2):224. https://doi.org/10.3390/ijms17020224
Chicago/Turabian StyleBjörnsson, Einar S. 2016. "Hepatotoxicity by Drugs: The Most Common Implicated Agents" Int. J. Mol. Sci. 17, no. 2: 224. https://doi.org/10.3390/ijms17020224
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