Hepatotoxicity by Drugs: The Most Common Implicated Agents

Björnsson, Einar

doi:10.3390/ijms17020224

Volume 17, Issue 2

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Int. J. Mol. Sci. 2016, 17(2), 224; https://doi.org/10.3390/ijms17020224

Hepatotoxicity by Drugs: The Most Common Implicated Agents

Einar S. Björnsson

Department of Internal Medicine, Division of Gastroenterology and Hepatology, The National University Hospital of Iceland and The Faculty of Medicine, The University of Iceland, 108 Reykjavik, Iceland

Received: 4 January 2016 / Revised: 28 January 2016 / Accepted: 1 February 2016 / Published: 6 February 2016

(This article belongs to the Special Issue Drug, Herb, and Dietary Supplement Hepatotoxicity)

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Abstract

Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury. Only 48 drugs had more than 50 case reports of DILI. Amoxicillin-clavulanate is the most commonly implicated agent leading to DILI in the prospective series. In a recent prospective study, liver injury due to amoxicillin-clavulanate was found to occur in approximately one out of 2300 users. Drugs with the highest risk of DILI in this study were azathioprine and infliximab. View Full-Text

Keywords: hepatotoxicity; drugs; drug-induced liver injury; idiosyncratic

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).