Next Article in Journal
Temporal Genetic Modifications after Controlled Cortical Impact—Understanding Traumatic Brain Injury through a Systematic Network Approach
Next Article in Special Issue
Herbal Medicine in Mexico: A Cause of Hepatotoxicity. A Critical Review
Previous Article in Journal
Micellization Behavior of Long-Chain Substituted Alkylguanidinium Surfactants
Previous Article in Special Issue
Drug-Induced Liver Injury Network Causality Assessment: Criteria and Experience in the United States
Open AccessReview

Hepatotoxicity by Drugs: The Most Common Implicated Agents

Department of Internal Medicine, Division of Gastroenterology and Hepatology, The National University Hospital of Iceland and The Faculty of Medicine, The University of Iceland, 108 Reykjavik, Iceland
Int. J. Mol. Sci. 2016, 17(2), 224; https://doi.org/10.3390/ijms17020224
Received: 4 January 2016 / Revised: 28 January 2016 / Accepted: 1 February 2016 / Published: 6 February 2016
(This article belongs to the Special Issue Drug, Herb, and Dietary Supplement Hepatotoxicity)
Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury. Only 48 drugs had more than 50 case reports of DILI. Amoxicillin-clavulanate is the most commonly implicated agent leading to DILI in the prospective series. In a recent prospective study, liver injury due to amoxicillin-clavulanate was found to occur in approximately one out of 2300 users. Drugs with the highest risk of DILI in this study were azathioprine and infliximab. View Full-Text
Keywords: hepatotoxicity; drugs; drug-induced liver injury; idiosyncratic hepatotoxicity; drugs; drug-induced liver injury; idiosyncratic
MDPI and ACS Style

Björnsson, E.S. Hepatotoxicity by Drugs: The Most Common Implicated Agents. Int. J. Mol. Sci. 2016, 17, 224. https://doi.org/10.3390/ijms17020224

AMA Style

Björnsson ES. Hepatotoxicity by Drugs: The Most Common Implicated Agents. International Journal of Molecular Sciences. 2016; 17(2):224. https://doi.org/10.3390/ijms17020224

Chicago/Turabian Style

Björnsson, Einar S. 2016. "Hepatotoxicity by Drugs: The Most Common Implicated Agents" Int. J. Mol. Sci. 17, no. 2: 224. https://doi.org/10.3390/ijms17020224

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop