Next Article in Journal
Canine Models for Copper Homeostasis Disorders
Next Article in Special Issue
Hepatotoxicity by Drugs: The Most Common Implicated Agents
Previous Article in Journal
Use of Repetitive Sequences for Molecular and Cytogenetic Characterization of Avena Species from Portugal
Previous Article in Special Issue
Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview

Drug-Induced Liver Injury Network Causality Assessment: Criteria and Experience in the United States

University of North Carolina Liver Center, 8011 Burnett-Womack Building, Chapel Hill, NC 27599-8754, USA
Academic Editor: Rolf Teschke
Int. J. Mol. Sci. 2016, 17(2), 201;
Received: 10 January 2016 / Revised: 27 January 2016 / Accepted: 28 January 2016 / Published: 4 February 2016
(This article belongs to the Special Issue Drug, Herb, and Dietary Supplement Hepatotoxicity)
PDF [721 KB, uploaded 4 February 2016]


Hepatotoxicity due to drugs, herbal or dietary supplements remains largely a clinical diagnosis based on meticulous history taking and exclusion of other causes of liver injury. In 2004, the U.S. Drug-Induced Liver Injury Network (DILIN) was created under the auspices of the U.S. National Institute of Diabetes and Digestive and Kidney Diseases with the aims of establishing a large registry of cases for clinical, epidemiological and mechanistic study. From inception, the DILIN has used an expert opinion process that incorporates consensus amongst three different DILIN hepatologists assigned to each case. It is the most well-established, well-described and vigorous expert opinion process for DILI to date, and yet it is an imperfect standard. This review will discuss the DILIN expert opinion process, its strengths and weaknesses, psychometric performance and future. View Full-Text
Keywords: hepatotoxicity; causality; diagnosis; expert opinion hepatotoxicity; causality; diagnosis; expert opinion

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Hayashi, P.H. Drug-Induced Liver Injury Network Causality Assessment: Criteria and Experience in the United States. Int. J. Mol. Sci. 2016, 17, 201.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top