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Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wanning 571533, China
Canadian Food and Wine Institute, Niagara College, 135 Taylor Road, Niagara-on-the-Lake, ON L0S 1J0, Canada
School of Chemical Sciences, University of Auckland, Private Bag 92019, New Zealand
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: David Arráez-Román
Int. J. Mol. Sci. 2016, 17(11), 1855;
Received: 11 September 2016 / Revised: 23 October 2016 / Accepted: 1 November 2016 / Published: 8 November 2016
(This article belongs to the Special Issue Lipidomics and Glycomics: New Advances in Food Science and Nutrition)
PDF [1539 KB, uploaded 8 November 2016]


This study was to investigate the bidirectional estrogen-like effects of genistein on murine experimental autoimmune ovarian disease (AOD). Female BALB/c mice were induced by immunization with a peptide from murine zona pellucida. The changes of estrous cycle, ovarian histomorphology were measured, and the levels of serum sex hormone were analyzed using radioimmunoassay. Proliferative responses of the ovary were also determined by immunohistochemistry. Administration of 25 or 45 mg/kg body weight genistein enhanced ovary development with changes in serum sex hormone levels and proliferative responses. Meanwhile, the proportions of growing and mature follicles increased and the incidence of autoimmune oophoritis decreased, which exhibited normal ovarian morphology in administration of 25 or 45 mg/kg body weight genistein, while a lower dose (5 mg/kg body weight genistein) produced the opposite effect. These findings suggest that genistein exerts bidirectional estrogen-like effects on murine experimental AOD, while a high dose (45 mg/kg body weight) of genistein may suppress AOD. View Full-Text
Keywords: autoimmune ovarian disease; genistein; zona pellucida; oophoritis; estradiol autoimmune ovarian disease; genistein; zona pellucida; oophoritis; estradiol

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ding, Q.; Wang, Y.; Li, N.; Zhu, K.; Hu, J.; Wang, S.; Zhu, F.; Nie, S. Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease. Int. J. Mol. Sci. 2016, 17, 1855.

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