Next Article in Journal
Comparative Transcriptional Analysis of Loquat Fruit Identifies Major Signal Networks Involved in Fruit Development and Ripening Process
Next Article in Special Issue
Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease
Previous Article in Journal
Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation
Previous Article in Special Issue
Determination of Free-Form and Peptide Bound Pyrraline in the Commercial Drinks Enriched with Different Protein Hydrolysates
Open AccessReview

Lipidomics—Reshaping the Analysis and Perception of Type 2 Diabetes

1
Institute for Clinical Diabetology, German Diabetes Center, c/o Auf’m Hennekamp 65, D-40225 Düsseldorf, Germany
2
German Center for Diabetes Research (DZD e.V.), München, D-85764 Neuherberg, Germany
3
Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, c/o Auf’m Hennekamp 65, D-40225 Düsseldorf, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: David Arráez-Román
Int. J. Mol. Sci. 2016, 17(11), 1841; https://doi.org/10.3390/ijms17111841
Received: 28 September 2016 / Revised: 28 October 2016 / Accepted: 31 October 2016 / Published: 4 November 2016
(This article belongs to the Special Issue Lipidomics and Glycomics: New Advances in Food Science and Nutrition)
As a consequence of a sedentary lifestyle as well as changed nutritional behavior, today’s societies are challenged by the rapid propagation of metabolic disorders. A common feature of diseases, such as obesity and type 2 diabetes (T2D), is the dysregulation of lipid metabolism. Our understanding of the mechanisms underlying these diseases is hampered by the complexity of lipid metabolic pathways on a cellular level. Furthermore, overall lipid homeostasis in higher eukaryotic organisms needs to be maintained by a highly regulated interplay between tissues, such as adipose tissue, liver and muscle. Unraveling pathological mechanisms underlying metabolic disorders therefore requires a diversified approach, integrating basic cellular research with clinical research, ultimately relying on the analytical power of mass spectrometry-based techniques. Here, we discuss recent progress in the development of lipidomics approaches to resolve the pathological mechanisms of metabolic diseases and to identify suitable biomarkers for clinical application. Due to its growing impact worldwide, we focus on T2D to highlight the key role of lipidomics in our current understanding of this disease, discuss remaining questions and suggest future strategies to address them. View Full-Text
Keywords: lipidomics; lipid metabolism; metabolic disorder; diabetes; type 2 diabetes; lipid induced insulin resistance; diacylglycerol (DAG); ceramide (CER) lipidomics; lipid metabolism; metabolic disorder; diabetes; type 2 diabetes; lipid induced insulin resistance; diacylglycerol (DAG); ceramide (CER)
Show Figures

Graphical abstract

MDPI and ACS Style

Markgraf, D.F.; Al-Hasani, H.; Lehr, S. Lipidomics—Reshaping the Analysis and Perception of Type 2 Diabetes. Int. J. Mol. Sci. 2016, 17, 1841.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop