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Int. J. Mol. Sci. 2016, 17(11), 1807;

The Gas6/TAM System and Multiple Sclerosis

Department of Translational Medicine, Università del Piemonte Orientale, UPO, via Solaroli 17, 28100 Novara, Italy
Immuno-rheumatology Unit, Internal Medicine Division, “Maggiore della Carità” Hospital, 28100 Novara, Italy
IRCAD, Interdisciplinary Research Center of Autoimmune Diseases, 28100 Novara, Italy
Author to whom correspondence should be addressed.
Academic Editor: Christoph Kleinschnitz
Received: 16 September 2016 / Revised: 22 October 2016 / Accepted: 26 October 2016 / Published: 28 October 2016
(This article belongs to the Special Issue Advances in Multiple Sclerosis 2016)
Full-Text   |   PDF [814 KB, uploaded 28 October 2016]   |  


Growth arrest specific 6 (Gas6) is a multimodular circulating protein, the biological actions of which are mediated by the interaction with three transmembrane tyrosine kinase receptors: Tyro3, Axl, and MerTK, collectively named TAM. Over the last few decades, many progresses have been done in the understanding of the biological activities of this highly pleiotropic system, which plays a role in the regulation of immune response, inflammation, coagulation, cell growth, and clearance of apoptotic bodies. Recent findings have further related Gas6 and TAM receptors to neuroinflammation in general and, specifically, to multiple sclerosis (MS). In this paper, we review the biology of the Gas6/TAM system and the current evidence supporting its potential role in the pathogenesis of MS. View Full-Text
Keywords: Gas6; TAM receptors; Axl; MerTK; Tyro3; multiple sclerosis Gas6; TAM receptors; Axl; MerTK; Tyro3; multiple sclerosis

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Bellan, M.; Pirisi, M.; Sainaghi, P.P. The Gas6/TAM System and Multiple Sclerosis. Int. J. Mol. Sci. 2016, 17, 1807.

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