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Int. J. Mol. Sci. 2016, 17(10), 1723;

The Inflammatory Role of Platelets: Translational Insights from Experimental Studies of Autoimmune Disorders

Department of Neurology, University of Münster, 48149 Münster, Germany
Department of Neurology, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany
Department of Anesthesiology, Intensive Care and Pain Medicine, Experimental and Clinical Hemostasis, University of Münster, 48149 Münster, Germany
University Clinic for Cardiology and Cardiovascular Medicine, Eberhard Karls-University Tübingen, 72076 Tübingen, Germany
Section for Cardioimmunology, Eberhard Karls-University Tübingen, 72076 Tübingen, Germany
Department of Neurology, University Hospital Essen, 45147 Essen, Germany
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Cesar Borlongan
Received: 7 September 2016 / Revised: 4 October 2016 / Accepted: 8 October 2016 / Published: 14 October 2016
(This article belongs to the Special Issue Advances in Multiple Sclerosis 2016)
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Beyond their indispensable role in hemostasis, platelets have shown to affect the development of inflammatory disorders, as they have been epidemiologically and mechanistically linked to diseases featuring an inflammatory reaction in inflammatory diseases like multiple sclerosis, rheumatoid arthritis and inflammatory bowel disorders. The identification of novel molecular mechanisms linking inflammation and to platelets has highlighted them as new targets for therapeutic interventions. In particular, genetic and pharmacological studies have identified an important role for platelets in neuroinflammation. This review summarizes the main molecular links between platelets and inflammation, focusing on immune regulatory factors, receptors, cellular targets and signaling pathways by which they can amplify inflammatory reactions and that make them potential therapeutic targets. View Full-Text
Keywords: platelets; autoimmunity; neuroinflammation platelets; autoimmunity; neuroinflammation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Pankratz, S.; Bittner, S.; Kehrel, B.E.; Langer, H.F.; Kleinschnitz, C.; Meuth, S.G.; Göbel, K. The Inflammatory Role of Platelets: Translational Insights from Experimental Studies of Autoimmune Disorders. Int. J. Mol. Sci. 2016, 17, 1723.

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