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Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias

The Warren Alpert Medical School of Brown University, Lifespan Cardiovascular Institute, the Providence VA Medical Center, 593 Eddy Street, APC814, Providence, RI 02903, USA
Author to whom correspondence should be addressed.
Academic Editor: Masato Matsuoka
Int. J. Mol. Sci. 2016, 17(1), 52;
Received: 24 November 2015 / Revised: 14 December 2015 / Accepted: 16 December 2015 / Published: 31 December 2015
(This article belongs to the Special Issue Modulators of Endoplasmic Reticulum Stress)
PDF [507 KB, uploaded 31 December 2015]


The unfolded protein response (UPR) has been extensively investigated in neurological diseases and diabetes, while its function in heart disease is less well understood. Activated UPR participates in multiple cardiac conditions and can either protect or impair heart function. Recently, the UPR has been found to play a role in arrhythmogenesis during human heart failure by affecting cardiac ion channels expression, and blocking UPR has an antiarrhythmic effect. This review will discuss the rationale for and challenges to targeting UPR in heart disease for treatment of arrhythmias. View Full-Text
Keywords: PERK; IRE1; ATF6α; Grp78; cardiac ion channels; ischemia PERK; IRE1; ATF6α; Grp78; cardiac ion channels; ischemia

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Liu, M.; Dudley, S.C., Jr. Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias. Int. J. Mol. Sci. 2016, 17, 52.

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