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Int. J. Mol. Sci. 2016, 17(1), 49;

The Anti-Inflammatory Compound Curcumin Enhances Locomotor and Sensory Recovery after Spinal Cord Injury in Rats by Immunomodulation

Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, Prague 142 20, Czech Republic
Department of Neuroscience, Charles University, Second Faculty of Medicine, Prague 142 20, Czech Republic
New York Medical College, New York, NY 10595, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Katalin Prokai-Tatrai
Received: 11 November 2015 / Revised: 23 December 2015 / Accepted: 23 December 2015 / Published: 31 December 2015
(This article belongs to the Special Issue Neuroprotective Strategies 2015)
Full-Text   |   PDF [2388 KB, uploaded 31 December 2015]   |  


Well known for its anti-oxidative and anti-inflammation properties, curcumin is a polyphenol found in the rhizome of Curcuma longa. In this study, we evaluated the effects of curcumin on behavioral recovery, glial scar formation, tissue preservation, axonal sprouting, and inflammation after spinal cord injury (SCI) in male Wistar rats. The rats were randomized into two groups following a balloon compression injury at the level of T9–T10 of the spinal cord, namely vehicle- or curcumin-treated. Curcumin was applied locally on the surface of the injured spinal cord immediately following injury and then given intraperitoneally daily; the control rats were treated with vehicle in the same manner. Curcumin treatment improved behavioral recovery within the first week following SCI as evidenced by improved Basso, Beattie, and Bresnahan (BBB) test and plantar scores, representing locomotor and sensory performance, respectively. Furthermore, curcumin treatment decreased glial scar formation by decreasing the levels of MIP1α, IL-2, and RANTES production and by decreasing NF-κB activity. These results, therefore, demonstrate that curcumin has a profound anti-inflammatory therapeutic potential in the treatment of spinal cord injury, especially when given immediately after the injury. View Full-Text
Keywords: spinal cord injury; curcumin; inflammation; cytokines; secondary processes; NF-κB spinal cord injury; curcumin; inflammation; cytokines; secondary processes; NF-κB

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Machova Urdzikova, L.; Karova, K.; Ruzicka, J.; Kloudova, A.; Shannon, C.; Dubisova, J.; Murali, R.; Kubinova, S.; Sykova, E.; Jhanwar-Uniyal, M.; Jendelova, P. The Anti-Inflammatory Compound Curcumin Enhances Locomotor and Sensory Recovery after Spinal Cord Injury in Rats by Immunomodulation. Int. J. Mol. Sci. 2016, 17, 49.

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