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Review

Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration

by
Ignacio Herraiz
1,
Elisa Simón
1,
Paula Isabel Gómez-Arriaga
1,
José Manuel Martínez-Moratalla
1,
Antonio García-Burguillo
1,
Elena Ana López Jiménez
2 and
Alberto Galindo
1,*
1
Fetal Medicine Unit-Maternal and Child Health and Development Network (SAMID), Department of Obstetrics and Gynaecology, Hospital Universitario "12 de Octubre", Universidad Complutense de Madrid, 28041 Madrid, Spain
2
Department of Clinical Biochemistry, Hospital Universitario "12 de Octubre", Universidad Complutense de Madrid, 28041 Madrid, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2015, 16(8), 19009-19026; https://doi.org/10.3390/ijms160819009
Submission received: 30 June 2015 / Revised: 27 July 2015 / Accepted: 3 August 2015 / Published: 13 August 2015
(This article belongs to the Special Issue Prediction, Diagnostics and Prevention of Pregnancy Complications)
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Abstract

Placental dysfunction is involved in a group of obstetrical conditions including preeclampsia, intrauterine growth restriction, and placental abruption. Their timely and accurate recognition is often a challenge since diagnostic criteria are still based on nonspecific signs and symptoms. The discovering of the role of angiogenic-related factors (sFlt-1/PlGF) in the underlying pathophysiology of placental dysfunction, taking into account that angiogenesis-related biomarkers are not specific to any particular placental insufficiency-related disease, has marked an important step for improving their early diagnosis and prognosis assessment. However, sFlt-1/PlGF has not been yet established as a part of most guidelines. We will review the current evidence on the clinical utility of sFlt-1/PlGF and propose a new protocol for its clinical integration.
Keywords: placental insufficiency; preeclampsia; intrauterine growth restriction; placental abruption; angiogenesis; sFlt-1; PlGF placental insufficiency; preeclampsia; intrauterine growth restriction; placental abruption; angiogenesis; sFlt-1; PlGF
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MDPI and ACS Style

Herraiz, I.; Simón, E.; Gómez-Arriaga, P.I.; Martínez-Moratalla, J.M.; García-Burguillo, A.; Jiménez, E.A.L.; Galindo, A. Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration. Int. J. Mol. Sci. 2015, 16, 19009-19026. https://doi.org/10.3390/ijms160819009

AMA Style

Herraiz I, Simón E, Gómez-Arriaga PI, Martínez-Moratalla JM, García-Burguillo A, Jiménez EAL, Galindo A. Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration. International Journal of Molecular Sciences. 2015; 16(8):19009-19026. https://doi.org/10.3390/ijms160819009

Chicago/Turabian Style

Herraiz, Ignacio, Elisa Simón, Paula Isabel Gómez-Arriaga, José Manuel Martínez-Moratalla, Antonio García-Burguillo, Elena Ana López Jiménez, and Alberto Galindo. 2015. "Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration" International Journal of Molecular Sciences 16, no. 8: 19009-19026. https://doi.org/10.3390/ijms160819009

APA Style

Herraiz, I., Simón, E., Gómez-Arriaga, P. I., Martínez-Moratalla, J. M., García-Burguillo, A., Jiménez, E. A. L., & Galindo, A. (2015). Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration. International Journal of Molecular Sciences, 16(8), 19009-19026. https://doi.org/10.3390/ijms160819009

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