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Open AccessReview

Combined Screening for Early Detection of Pre-Eclampsia

Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul 135-081, Korea
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Philip Newton Baker
Int. J. Mol. Sci. 2015, 16(8), 17952-17974; https://doi.org/10.3390/ijms160817952
Received: 30 April 2015 / Revised: 21 July 2015 / Accepted: 22 July 2015 / Published: 4 August 2015
(This article belongs to the Special Issue Prediction, Diagnostics and Prevention of Pregnancy Complications)
Although the precise pathophysiology of pre-eclampsia remains unknown, this condition continues to be a major cause of maternal and fetal mortality. Early prediction of pre-eclampsia would allow for timely initiation of preventive therapy. A combination of biophysical and biochemical markers are superior to other tests for early prediction of the development of pre-eclampsia. Apart from the use of parameters in first-trimester aneuploidy screening, cell-free fetal DNA quantification is emerging as a promising marker for prediction of pre-eclampsia. This article reviews the current research of the most important strategies for prediction of pre-eclampsia, including the use of maternal risk factors, mean maternal arterial pressure, ultrasound parameters, and biomarkers. View Full-Text
Keywords: pre-eclampsia; early prediction; maternal risk factors; mean maternal arterial pressure; ultrasound parameters; biomarker; pregnancy-associated plasma protein-A (PAPP-A); cell-free fetal DNA pre-eclampsia; early prediction; maternal risk factors; mean maternal arterial pressure; ultrasound parameters; biomarker; pregnancy-associated plasma protein-A (PAPP-A); cell-free fetal DNA
MDPI and ACS Style

Park, H.J.; Shim, S.S.; Cha, D.H. Combined Screening for Early Detection of Pre-Eclampsia. Int. J. Mol. Sci. 2015, 16, 17952-17974.

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