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Int. J. Mol. Sci. 2015, 16(8), 17445-17455;

Effects of Surface-Deacetylated Chitin Nanofibers in an Experimental Model of Hypercholesterolemia

Department of Clinical Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan
Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan
Japan Food Research Laboratories, Tama 206-0025, Japan
Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University, Tottori 680-8550, Japan
Authors to whom correspondence should be addressed.
Academic Editor: Hitoshi Sashiwa
Received: 6 July 2015 / Revised: 23 July 2015 / Accepted: 23 July 2015 / Published: 30 July 2015
(This article belongs to the Special Issue Chitins 2015)
Full-Text   |   PDF [650 KB, uploaded 30 July 2015]


This study evaluated the effects of oral administration of surface-deacetylated chitin nanofibers (SDACNFs) on hypercholesterolemia using an experimental model. All rats were fed a high cholesterol diet with 1% w/w cholesterol and 0.5% w/w cholic acid for 28 days. Rats were divided equally into four groups: the control group was administered 0.05% acetic acid dissolved in tap water, and the SDACNF, chitosan (CS), and cellulose nanofiber (CLNF) groups were administered 0.1% CNF, CS, or CLNF dissolved in the tap water, respectively, during the experimental period. Changes in body weight, intake of food and water, and organ weight were measured. Serum blood chemistry and histopathological examination of the liver were performed. Administration of SDACNF did not affect body weight change, food and water intake, or organ weights. Administration of SDACNF and CS decreased the diet-induced increase in serum total cholesterol, chylomicron, very-low-density lipoprotein, and phospholipid levels on day 14. Moreover, oral administration of SDACNFs suppressed the increase of alanine transaminase levels on day 29 and suppressed vacuolar degeneration and accumulation of lipid droplets in liver tissue. These data indicate that SDACNF has potential as a functional food for patients with hypercholesterolemia. View Full-Text
Keywords: surface-deacetylated chitin nanofibers; chitin nanofibers; chitosan; hypercholesterolemia; rats surface-deacetylated chitin nanofibers; chitin nanofibers; chitosan; hypercholesterolemia; rats
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Azuma, K.; Nagae, T.; Nagai, T.; Izawa, H.; Morimoto, M.; Murahata, Y.; Osaki, T.; Tsuka, T.; Imagawa, T.; Ito, N.; Okamoto, Y.; Saimoto, H.; Ifuku, S. Effects of Surface-Deacetylated Chitin Nanofibers in an Experimental Model of Hypercholesterolemia. Int. J. Mol. Sci. 2015, 16, 17445-17455.

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