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Int. J. Mol. Sci. 2015, 16(8), 18328-18347;

Chitosan in Molecularly-Imprinted Polymers: Current and Future Prospects

1,2,* and 1
School of Liquor & Food Engineering, Guizhou University, Guiyang 550025, China
Key Laboratory of Agricultural & Animal Products Store and Processing of Guizhou Province, Guiyang 550025, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Hitoshi Sashiwa
Received: 29 June 2015 / Revised: 29 July 2015 / Accepted: 30 July 2015 / Published: 7 August 2015
(This article belongs to the Special Issue Chitins 2015)
Full-Text   |   PDF [849 KB, uploaded 7 August 2015]   |  


Chitosan is widely used in molecular imprinting technology (MIT) as a functional monomer or supporting matrix because of its low cost and high contents of amino and hydroxyl functional groups. The various excellent properties of chitosan, which include nontoxicity, biodegradability, biocompatibility, and attractive physical and mechanical performances, make chitosan a promising alternative to conventional functional monomers. Recently, chitosan molecularly-imprinted polymers have gained considerable attention and showed significant potential in many fields, such as curbing environmental pollution, medicine, protein separation and identification, and chiral-compound separation. These extensive applications are due to the polymers’ desired selectivity, physical robustness, and thermal stability, as well as their low cost and easy preparation. Cross-linkers, which fix the functional groups of chitosan around imprinted molecules, play an important role in chitosan molecularly-imprinted polymers. This review summarizes the important cross-linkers of chitosan molecularly-imprinted polymers and illustrates the cross-linking mechanism of chitosan and cross-linkers based on the two glucosamine units. Finally, some significant attempts to further develop the application of chitosan in MIT are proposed. View Full-Text
Keywords: chitosan; molecularly imprinted polymers; cross-linkers; aldehydes; heterocyclic compounds chitosan; molecularly imprinted polymers; cross-linkers; aldehydes; heterocyclic compounds

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Xu, L.; Huang, Y.-A.; Zhu, Q.-J.; Ye, C. Chitosan in Molecularly-Imprinted Polymers: Current and Future Prospects. Int. J. Mol. Sci. 2015, 16, 18328-18347.

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