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Recent Breakthroughs in the Antioxidant and Anti-Inflammatory Effects of Morella and Myrica Species

Department of Technological Science and Development, University of Azores, Ponta Delgada 9501-801, Portugal
Department of Chemistry & Química Orgânica Produtos Naturais and Agroalimentares, University of Aveiro, Aveiro 3810-193, Portugal
Centro Investigação Recursos Naturais, University of Azores, Ponta Delgada 9501-801, Portugal
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Guido Haenen
Int. J. Mol. Sci. 2015, 16(8), 17160-17180;
Received: 28 June 2015 / Revised: 13 July 2015 / Accepted: 14 July 2015 / Published: 28 July 2015
(This article belongs to the Special Issue Antioxidant 2.0——Redox Modulation by Food and Drugs)
PDF [796 KB, uploaded 28 July 2015]


Oxidative stress is one of the risk factors for the development of several chronic diseases, such as diabetes, cancer, cardiovascular and neurodegenerative diseases. Antioxidants are therefore highly sought and can be seen as a type of preventive medicine against several diseases. Myrica and Morella genus (Myricaceae) are taxonomically very close and their species are trees or shrubs with edible fruits that exhibit relevant uses in traditional medicine, for instance in Chinese or Japanese folk medicine they are used to treat diarrhea, digestive problems, headache, burns and skin diseases. Nearly 36 compounds were isolated from different morphological parts of Myrica and/or Morella species and their antioxidant and anti-inflammatory activities evaluated. Thirteen of these compounds exhibit greater effects than the positive controls used. Adenodimerin A was the most active compound reported (in a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay EC50= 7.9 ± 0.3 µM). These results are just one aspect of the antioxidant and anti-inflammatory evaluations reported regarding Myrica and Morella species, so a comprehensive overview on the current status, highlighting the antioxidant health promoting effect of these species, their key antioxidant compounds as well as the compounds with protective effects against oxidative stress related diseases such as inflammation, is relevant. View Full-Text
Keywords: Morella; Myrica; antioxidant; anti-inflammatory; flavonoids; diarylheptanoid Morella; Myrica; antioxidant; anti-inflammatory; flavonoids; diarylheptanoid

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Silva, B.J.C.; Seca, A.M.L.; Barreto, M.D.C.; Pinto, D.C.G.A. Recent Breakthroughs in the Antioxidant and Anti-Inflammatory Effects of Morella and Myrica Species. Int. J. Mol. Sci. 2015, 16, 17160-17180.

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