Next Article in Journal
14-3-3γ Regulates Lipopolysaccharide-Induced Inflammatory Responses and Lactation in Dairy Cow Mammary Epithelial Cells by Inhibiting NF-κB and MAPKs and Up-Regulating mTOR Signaling
Next Article in Special Issue
miR-199a and miR-497 Are Associated with Better Overall Survival due to Increased Chemosensitivity in Diffuse Large B-Cell Lymphoma Patients
Previous Article in Journal
B Cells and Autoantibodies in Multiple Sclerosis
Previous Article in Special Issue
Families of microRNAs Expressed in Clusters Regulate Cell Signaling in Cervical Cancer
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview

What Do We Know about the Role of miRNAs in Pediatric Sarcoma?

The National Children's Research Centre, Lady's Children's Hospital, Crumlin, Dublin 12, Ireland
Histology Laboratory, Lady's Children's Hospital, Crumlin, Dublin 12, Ireland
Trinity College, University of Dublin, Dublin 2, Ireland
Author to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Int. J. Mol. Sci. 2015, 16(7), 16593-16621;
Received: 29 May 2015 / Revised: 10 July 2015 / Accepted: 15 July 2015 / Published: 22 July 2015
(This article belongs to the Collection Regulation by Non-Coding RNAs)
PDF [870 KB, uploaded 22 July 2015]


Non-coding RNAs have received a lot of attention in recent years, with especial focus on microRNAs (miRNAs), so much so that in the just over two decades since the first miRNA, Lin4, was described, almost 40,000 publications about miRNAs have been generated. Less than 500 of these focus on sarcoma, and only a fraction of those on sarcomas of childhood specifically, with some of these representing observational studies and others containing functionally validated data. This is a group of cancers for which prognosis is often poor and therapeutic options limited, and it is especially in these areas that strides in understanding the role of non-coding RNAs and miRNAs in particular are to be welcomed. This review deals with the main forms of pediatric sarcoma, exploring what is known about the diagnostic and prognostic profiles of miRNAs in these tumours and where novel therapeutic options might present themselves for further exploration. View Full-Text
Keywords: microRNA; regulation of gene expression; pediatric; sarcoma microRNA; regulation of gene expression; pediatric; sarcoma

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Kelly, L.C.; Lázaro, A.; O'Sullivan, M.J. What Do We Know about the Role of miRNAs in Pediatric Sarcoma? Int. J. Mol. Sci. 2015, 16, 16593-16621.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top