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Int. J. Mol. Sci. 2015, 16(6), 11849-11863;

Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects

Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110013, China
Division of Molecular Preventive Medicine, Shanghai Institute of Targeted Therapy and Molecular Medicine, Shanghai 200433, China
Brain Disease Center, Tianjin Dagang Oil Field General Hospital, Tianjin 300280, China
Author to whom correspondence should be addressed.
Academic Editor: Emil Alexov
Received: 31 March 2015 / Accepted: 15 May 2015 / Published: 26 May 2015
(This article belongs to the Collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
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Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings. View Full-Text
Keywords: MTHFR; MTRR; overweight; obesity; polymorphism MTHFR; MTRR; overweight; obesity; polymorphism

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Fan, S.-J.; Yang, B.-Y.; Zhi, X.-Y.; He, M.; Wang, D.; Wang, Y.-X.; Wang, Y.-N.; Wei, J.; Zheng, Q.-M.; Sun, G.-F. Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects. Int. J. Mol. Sci. 2015, 16, 11849-11863.

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