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Int. J. Mol. Sci. 2015, 16(5), 10016-10037;

Instrumentation on Multi-Scaled Scattering of Bio-Macromolecular Solutions

Chemistry Department, Stony Brook University, Stony Brook, New York, NY 11794-3400, USA
Author to whom correspondence should be addressed.
Academic Editor: Herbert Schneckenburger
Received: 24 March 2015 / Revised: 14 April 2015 / Accepted: 22 April 2015 / Published: 4 May 2015
(This article belongs to the Special Issue Laser Application in Life Sciences)
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The design, construction and initial tests on a combined laser light scattering and synchrotron X-ray scattering instrument can cover studies of length scales from atomic sizes in Angstroms to microns and dynamics from microseconds to seconds are presented. In addition to static light scattering (SLS), dynamic light scattering (DLS), small angle X-ray scattering (SAXS) and wide angle X-ray diffraction (WAXD), the light scattering instrument is being developed to carry out studies in mildly turbid solutions, in the presence of multiple scattering. Three-dimensional photon cross correlation function (3D-PCCF) measurements have been introduced to couple with synchrotron X-ray scattering to study the structure, size and dynamics of macromolecules in solution. View Full-Text
Keywords: laser/X-ray scattering; photon cross correlation spectroscopy; size; structure; dynamics laser/X-ray scattering; photon cross correlation spectroscopy; size; structure; dynamics

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Chu, B.; Fang, D.; Mao, Y. Instrumentation on Multi-Scaled Scattering of Bio-Macromolecular Solutions. Int. J. Mol. Sci. 2015, 16, 10016-10037.

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