Next Article in Journal
Isolation and Molecular Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase Genes in Hevea brasiliensis
Next Article in Special Issue
Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics
Previous Article in Journal
The Actin Depolymerizing Factor (ADF)/Cofilin Signaling Pathway and DNA Damage Responses in Cancer
Previous Article in Special Issue
Detection of miRNA as Non-Invasive Biomarkers of Colorectal Cancer
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 16
Issue 2
10.3390/ijms16024121
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Genetic Polymorphisms in Estrogen-Related Genes and the Risk of Breast Cancer among Han Chinese Women

by
Min-Ying Sun
1,†,
Hong-Yan Du
2,†,
An-Na Zhu
2,
Hui-Ying Liang
1,
Gorka Ruiz De Garibay
3,
Fen-Xia Li
2,
Ming Li
2,* and
Xue-Xi Yang
2,*
1
Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
2
School of Biotechnology, Southern Medical University, Guangzhou 510515, China
3
Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research, Barcelona 08908, Spain
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2015, 16(2), 4121-4135; https://doi.org/10.3390/ijms16024121
Submission received: 3 November 2014 / Revised: 21 January 2015 / Accepted: 4 February 2015 / Published: 13 February 2015
(This article belongs to the Special Issue Emerging Classes of Biomarkers for Molecular Diagnostics)
Versions Notes

Abstract

Exposure to high levels of estrogen is considered an important risk factor for susceptibility to breast cancer. Common polymorphisms in genes that affect estrogen levels may be associated with breast cancer risk, but no comprehensive study has been performed among Han Chinese women. In the present study, 32 single-nucleotide polymorphisms (SNPs) in estrogen-related genes were genotyped using the MassARRAY IPLEX platform in 1076 Han Chinese women. Genotypic and allelic frequencies were compared between case and control groups. Unconditional logistic regression was used to assess the effects of SNPs on breast cancer risk. Associations were also evaluated for breast cancer subtypes stratified by estrogen receptor (ER) and progesterone receptor (PR) status. Case-control analysis showed a significant relation between heterozygous genotypes of rs700519 and rs2069522 and breast cancer risk (OR = 0.723, 95% CI = 0.541–0.965, p = 0.028 and OR = 1.500, 95% CI = 1.078–2.087, p = 0.016, respectively). Subgroup comparisons revealed that rs2446405 and rs17268974 were related to ER status, and rs130021 was associated with PR status. Our findings suggest that rs700519 and rs2069522 are associated with susceptibility to breast cancer among the Han Chinese population and have a cumulative effect with three other identified SNPs. Further genetic and functional studies are needed to identify additional SNPs, and to elucidate the underlying molecular mechanisms.
Keywords: estrogen; polymorphisms; breast cancer estrogen; polymorphisms; breast cancer

Share and Cite

MDPI and ACS Style

Sun, M.-Y.; Du, H.-Y.; Zhu, A.-N.; Liang, H.-Y.; De Garibay, G.R.; Li, F.-X.; Li, M.; Yang, X.-X. Genetic Polymorphisms in Estrogen-Related Genes and the Risk of Breast Cancer among Han Chinese Women. Int. J. Mol. Sci. 2015, 16, 4121-4135. https://doi.org/10.3390/ijms16024121

AMA Style

Sun M-Y, Du H-Y, Zhu A-N, Liang H-Y, De Garibay GR, Li F-X, Li M, Yang X-X. Genetic Polymorphisms in Estrogen-Related Genes and the Risk of Breast Cancer among Han Chinese Women. International Journal of Molecular Sciences. 2015; 16(2):4121-4135. https://doi.org/10.3390/ijms16024121

Chicago/Turabian Style

Sun, Min-Ying, Hong-Yan Du, An-Na Zhu, Hui-Ying Liang, Gorka Ruiz De Garibay, Fen-Xia Li, Ming Li, and Xue-Xi Yang. 2015. "Genetic Polymorphisms in Estrogen-Related Genes and the Risk of Breast Cancer among Han Chinese Women" International Journal of Molecular Sciences 16, no. 2: 4121-4135. https://doi.org/10.3390/ijms16024121

APA Style

Sun, M.-Y., Du, H.-Y., Zhu, A.-N., Liang, H.-Y., De Garibay, G. R., Li, F.-X., Li, M., & Yang, X.-X. (2015). Genetic Polymorphisms in Estrogen-Related Genes and the Risk of Breast Cancer among Han Chinese Women. International Journal of Molecular Sciences, 16(2), 4121-4135. https://doi.org/10.3390/ijms16024121

Article Metrics

Back to TopTop