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The Actin Depolymerizing Factor (ADF)/Cofilin Signaling Pathway and DNA Damage Responses in Cancer

by 1,†, 2,† and 1,3,*
1
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan
2
Division of Radiation Oncology, Taipei City Hospital RenAi Branch, Taipei 106, Taiwan
3
Biophotonics & Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei 112, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Guillermo T. Sáez
Int. J. Mol. Sci. 2015, 16(2), 4095-4120; https://doi.org/10.3390/ijms16024095
Received: 22 December 2014 / Revised: 26 January 2015 / Accepted: 9 February 2015 / Published: 13 February 2015
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases 2014)
The actin depolymerizing factor (ADF)/cofilin protein family is essential for actin dynamics, cell division, chemotaxis and tumor metastasis. Cofilin-1 (CFL-1) is a primary non-muscle isoform of the ADF/cofilin protein family accelerating the actin filamental turnover in vitro and in vivo. In response to environmental stimulation, CFL-1 enters the nucleus to regulate the actin dynamics. Although the purpose of this cytoplasm-nucleus transition remains unclear, it is speculated that the interaction between CFL-1 and DNA may influence various biological responses, including DNA damage repair. In this review, we will discuss the possible involvement of CFL-1 in DNA damage responses (DDR) induced by ionizing radiation (IR), and the implications for cancer radiotherapy. View Full-Text
Keywords: actin cytoskeleton; ADF/cofilin; radiosensitivity; DDR; radiotherapy actin cytoskeleton; ADF/cofilin; radiosensitivity; DDR; radiotherapy
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MDPI and ACS Style

Chang, C.-Y.; Leu, J.-D.; Lee, Y.-J. The Actin Depolymerizing Factor (ADF)/Cofilin Signaling Pathway and DNA Damage Responses in Cancer. Int. J. Mol. Sci. 2015, 16, 4095-4120. https://doi.org/10.3390/ijms16024095

AMA Style

Chang C-Y, Leu J-D, Lee Y-J. The Actin Depolymerizing Factor (ADF)/Cofilin Signaling Pathway and DNA Damage Responses in Cancer. International Journal of Molecular Sciences. 2015; 16(2):4095-4120. https://doi.org/10.3390/ijms16024095

Chicago/Turabian Style

Chang, Chun-Yuan, Jyh-Der Leu, and Yi-Jang Lee. 2015. "The Actin Depolymerizing Factor (ADF)/Cofilin Signaling Pathway and DNA Damage Responses in Cancer" International Journal of Molecular Sciences 16, no. 2: 4095-4120. https://doi.org/10.3390/ijms16024095

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