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Int. J. Mol. Sci. 2015, 16(12), 28401-28417;

Cytidine 5′-Diphosphocholine (Citicoline) in Glaucoma: Rationale of Its Use, Current Evidence and Future Perspectives

IRCCS-Fondazione GB Bietti, Via Livenza, 3, 00198 Rome, Italy
DSMC, Università degli studi di Brescia, USVD “Centro per lo studio del Glaucoma” P.le Spedali Civili, 1, 25123 Brescia, Italy
DSCMT, Università di Roma Tor Vergata, Viale Oxford 81, 00133 Rome, Italy
Authors to whom correspondence should be addressed.
Academic Editor: Katalin Prokai-Tatrai
Received: 31 October 2015 / Revised: 17 November 2015 / Accepted: 19 November 2015 / Published: 30 November 2015
(This article belongs to the Collection Neuroprotective Strategies)
Full-Text   |   PDF [561 KB, uploaded 30 November 2015]   |  


Cytidine 5′-diphosphocholine or citicoline is an endogenous compound that acts in the biosynthetic pathway of phospholipids of cell membranes, particularly phosphatidylcholine, and it is able to increase neurotrasmitters levels in the central nervous system. Citicoline has shown positive effects in Parkinson’s disease and Alzheimer’s disease, as well as in amblyopia. Glaucoma is a neurodegenerative disease currently considered a disease involving ocular and visual brain structures. Neuroprotection has been proposed as a valid therapeutic option for those patients progressing despite a well-controlled intraocular pressure, the main risk factor for the progression of the disease. The aim of this review is to critically summarize the current evidence about the effect of citicoline in glaucoma. View Full-Text
Keywords: citicoline; glaucoma; neuroprotection; retinal ganglion cells citicoline; glaucoma; neuroprotection; retinal ganglion cells

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Roberti, G.; Tanga, L.; Michelessi, M.; Quaranta, L.; Parisi, V.; Manni, G.; Oddone, F. Cytidine 5′-Diphosphocholine (Citicoline) in Glaucoma: Rationale of Its Use, Current Evidence and Future Perspectives. Int. J. Mol. Sci. 2015, 16, 28401-28417.

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