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Int. J. Mol. Sci. 2015, 16(12), 29069-29092;

Mast Cell-Mediated Mechanisms of Nociception

Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Author to whom correspondence should be addressed.
Academic Editor: Irmgard Tegeder
Received: 4 November 2015 / Revised: 28 November 2015 / Accepted: 1 December 2015 / Published: 4 December 2015
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Pain)
PDF [1007 KB, uploaded 7 December 2015]


Mast cells are tissue-resident immune cells that release immuno-modulators, chemo-attractants, vasoactive compounds, neuropeptides and growth factors in response to allergens and pathogens constituting a first line of host defense. The neuroimmune interface of immune cells modulating synaptic responses has been of increasing interest, and mast cells have been proposed as key players in orchestrating inflammation-associated pain pathobiology due to their proximity to both vasculature and nerve fibers. Molecular underpinnings of mast cell-mediated pain can be disease-specific. Understanding such mechanisms is critical for developing disease-specific targeted therapeutics to improve analgesic outcomes. We review molecular mechanisms that may contribute to nociception in a disease-specific manner. View Full-Text
Keywords: mast cells; pain; migraine; cytokines; cancer; inflammation; substance P; tryptase; hyperalgesia; sickle cell disease mast cells; pain; migraine; cytokines; cancer; inflammation; substance P; tryptase; hyperalgesia; sickle cell disease

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Aich, A.; Afrin, L.B.; Gupta, K. Mast Cell-Mediated Mechanisms of Nociception. Int. J. Mol. Sci. 2015, 16, 29069-29092.

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