Next Article in Journal
Differentially-Expressed Genes Associated with Faster Growth of the Pacific Abalone, Haliotis discus hannai
Next Article in Special Issue
Mast Cell-Mediated Mechanisms of Nociception
Previous Article in Journal
TriFabs—Trivalent IgG-Shaped Bispecific Antibody Derivatives: Design, Generation, Characterization and Application for Targeted Payload Delivery
Previous Article in Special Issue
Identification of Molecular Fingerprints in Human Heat Pain Thresholds by Use of an Interactive Mixture Model R Toolbox (AdaptGauss)

Age-Dependent Changes in the Inflammatory Nociceptive Behavior of Mice

pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
Author to whom correspondence should be addressed.
Academic Editor: Irmgard Tegeder
Int. J. Mol. Sci. 2015, 16(11), 27508-27519;
Received: 18 August 2015 / Revised: 3 November 2015 / Accepted: 5 November 2015 / Published: 18 November 2015
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Pain)
The processing of pain undergoes several changes in aging that affect sensory nociceptive fibers and the endogenous neuronal inhibitory systems. So far, it is not completely clear whether age-induced modifications are associated with an increase or decrease in pain perception. In this study, we assessed the impact of age on inflammatory nociception in mice and the role of the hormonal inhibitory systems in this context. We investigated the nociceptive behavior of 12-month-old versus 6–8-week-old mice in two behavioral models of inflammatory nociception. Levels of TRP channels, and cortisol as well as cortisol targets, were measured by qPCR, ELISA, and Western blot in the differently aged mice. We observed an age-related reduction in nociceptive behavior during inflammation as well as a higher level of cortisol in the spinal cord of aged mice compared to young mice, while TRP channels were not reduced. Among potential cortisol targets, the NF-κB inhibitor protein alpha (IκBα) was increased, which might contribute to inhibition of NF-κB and a decreased expression and activity of the inducible nitric oxide synthase (iNOS). In conclusion, our results reveal a reduced nociceptive response in aged mice, which might be at least partially mediated by an augmented inflammation-induced increase in the hormonal inhibitory system involving cortisol. View Full-Text
Keywords: nociception; inflammation; age; cortisol nociception; inflammation; age; cortisol
Show Figures

Graphical abstract

MDPI and ACS Style

King-Himmelreich, T.S.; Möser, C.V.; Wolters, M.C.; Olbrich, K.; Geisslinger, G.; Niederberger, E. Age-Dependent Changes in the Inflammatory Nociceptive Behavior of Mice. Int. J. Mol. Sci. 2015, 16, 27508-27519.

AMA Style

King-Himmelreich TS, Möser CV, Wolters MC, Olbrich K, Geisslinger G, Niederberger E. Age-Dependent Changes in the Inflammatory Nociceptive Behavior of Mice. International Journal of Molecular Sciences. 2015; 16(11):27508-27519.

Chicago/Turabian Style

King-Himmelreich, Tanya S., Christine V. Möser, Miriam C. Wolters, Katrin Olbrich, Gerd Geisslinger, and Ellen Niederberger. 2015. "Age-Dependent Changes in the Inflammatory Nociceptive Behavior of Mice" International Journal of Molecular Sciences 16, no. 11: 27508-27519.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop